Indirect parameters of pancreatic function in cystic fibrosis (CF) during a controlled double-blind trial of pancreatic supplementation
| Autor: | Barbier Y, Münch R, Henker J, Regele S, Stern M |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Pancreatic disease Adolescent Cystic Fibrosis Cystic fibrosis Excretion Feces fluids and secretions Double-Blind Method Gastrointestinal Agents Internal medicine medicine Chymotrypsin Humans Trypsin Child Pancreas business.industry Respiratory disease Gastroenterology Lipase medicine.disease Lipids Steatorrhea medicine.anatomical_structure Endocrinology Child Preschool Pediatrics Perinatology and Child Health Pancreatin Exocrine Pancreatic Insufficiency Female medicine.symptom business medicine.drug |
| Zdroj: | Journal of pediatric gastroenterology and nutrition. 22(1) |
| ISSN: | 0277-2116 |
| Popis: | During two treatment periods (4 weeks each), serum immunoreactive trypsin (IRT), immunoreactive human lipase in stool (IRL), and chymotrypsin (CT) activity in stool were determined in 16 cystic fibrosis patients and compared with fecal fat excretion (72-h sampling). Fecal fat estimation revealed mild to severe steatorrhea in all 16 patients (X = 13.7 +/- 9.0 g/24 h) in at least one study period. Stool fat excretion was highest in underweight adolescents and adults. Comparison of IRT and IRL with stool fat values showed no significant statistical correlation. IRT values revealed an inverse exponential correlation with age, with a steep decline at the age of 5 years. CT levels were very high in 14 of our 16 patients during supplementation therapy, whereas 2 patients showed subnormal CT values. We conclude that since indirect parameters of pancreatic function do not correlate with stool fat excretion, stool fat remains the best indirect parameter for the assessment of pancreatic insufficiency in cystic fibrosis. Leaving pancreatic enzyme supplementation in cystic fibrosis patients on the basis of normal serum trypsin or fecal lipase values does not appear to be adequate. |
| Databáze: | OpenAIRE |
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