Cell lines derived from pancreatic tumors of Tg(Ela-1-SV40E)Bri18 transgenic mice express somatostatin and antigen
| Autor: | Olive S. Pettengill, Vincent A. Memoli, Truls Brinck-Johnsen, Daniel S. Longnecker |
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| Rok vydání: | 1994 |
| Předmět: |
Cancer Research
medicine.medical_specialty Antigens Polyomavirus Transforming Transgene Cell Radioimmunoassay Mice Transgenic Biology Mice Internal medicine Tumor Cells Cultured medicine Acinar cell Animals Secretion geography geography.geographical_feature_category General Medicine Adenoma Islet Cell Islet Immunohistochemistry Molecular biology Pancreatic Neoplasms Microscopy Electron medicine.anatomical_structure Somatostatin Endocrinology Cell culture Pancreas Cell Division |
| Zdroj: | Carcinogenesis. 15:61-65 |
| ISSN: | 1460-2180 0143-3334 |
| DOI: | 10.1093/carcin/15.1.61 |
| Popis: | Continuous cell lines have been isolated from islet cell, small cell anaplastic and acinar cell carcinomas arising in the pancreas of transgenic mice, line Tg(Ela-1-SV40E)Bri18. These mice carry the pseudogene construct composed of elastase-1 promoter linked to the SV40 T antigen. Cells derived from islet cell or small cell anaplastic tumors secreted insulin and somatostatin during the early period of culture. Phenotypic alterations occurred during culture, whereby insulin secretion ceased and cells instead secreted somatostatin, indicating a change from beta-cell to delta-cell phenotype. Acinar cell lines did not secrete amylase or lipase. |
| Databáze: | OpenAIRE |
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