Talin and Kindlin as Integrin-Activating Proteins: Focus on the Heart
Autor: | Ana Maria Manso, Robert S. Ross, Chao Chen |
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Rok vydání: | 2019 |
Předmět: |
Talin
Integrins Integrin 030204 cardiovascular system & hematology Article Extracellular matrix 03 medical and health sciences 0302 clinical medicine Cell surface receptor Extracellular Medicine Myocyte Animals Humans Cytoskeleton biology business.industry Membrane Proteins Heart Cell biology Neoplasm Proteins 030228 respiratory system Cytoplasm Pediatrics Perinatology and Child Health biology.protein Cardiology and Cardiovascular Medicine business Intracellular Signal Transduction |
Zdroj: | Pediatr Cardiol |
ISSN: | 1432-1971 |
Popis: | Integrin receptors enable cells to sense and respond to their chemical and physical environment. As a class of membrane receptors, they provide a dynamic, tightly regulated link between the extracellular matrix or cellular counter-receptors and intracellular cytoskeletal and signaling networks. They enable transmission of mechanical force across the plasma membrane, and particularly for cardiomyocytes, may sense the mechanical load placed on cells. Talins and Kindlins are two families of FERM-domain proteins which bind the cytoplasmic tail of integrins, recruit cytoskeletal and signaling proteins involved in mechano-transduction, and those which synergize to activate integrins, allowing the integrins to physically change and bind to extracellular ligands. In this review, we will discuss the roles of talin and kindlin, particularly as integrin activators, with a focus on cardiac myocytes. |
Databáze: | OpenAIRE |
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