Association of IL-6 Polymorphism -174G/C and Metabolic Syndrome in Hypertensive Patients
| Autor: | Andrei Alkmim Teixeira, Marcelo Costa Batista, Beata Marie Redublo Quinto, Maria Aparecida Dalboni, Cassio José de Oliveira Rodrigues |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Article Subject Genotype Population lcsh:Medicine Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology Diabetes mellitus Internal medicine medicine Diabetes Mellitus Humans Genetic Predisposition to Disease Allele education Genotyping Alleles Genetic Association Studies Aged Metabolic Syndrome education.field_of_study Framingham Risk Score General Immunology and Microbiology business.industry Interleukin-6 lcsh:R General Medicine Middle Aged medicine.disease Endocrinology Hypertension Female Gene polymorphism Metabolic syndrome business Research Article |
| Zdroj: | BioMed Research International, Vol 2015 (2015) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Introduction. Visceral obesity, the central core of metabolic syndrome (MetS), is conceived as the pathogenic basis of an increased cardiovascular burden and is related with changes in cytokines. We investigated whether IL-6-174G/C gene polymorphism is associated with MetS prevalence in hypertensive patients.Method. A population of hypertensive patients was included and stratified by the presence of MetS according to IDF criteria and evaluated by Framingham risk score. The IL-6-174G/C genotyping was performed by polymerase chain reaction and the prevalence of MetS was compared between “C” carrier and “non-C” carrier groups.Results. From an original sample of 664 patients, 612 (34.2% men, age 57.3 ± 10.1, 30.4% diabetics) were included. MetS was diagnosed in 51.3% of total population and “C” carriers demonstrated high prevalence of MetS (P<0.05) and each of its components. On binary logistic regression, it was observed that the IL-6 polymorphism was independently associated with occurrence of MetS, even after adjusting for covariates (OR 1.13–2.37, 95% CI,P<0.05).Conclusion. The C allele at the -174 locus of IL-6 gene is independently associated with the occurrence of metabolic syndrome, emphasizing the importance of inflammatory genetic background in the pathogenesis of visceral obesity and related cardiovascular burden. |
| Databáze: | OpenAIRE |
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