Age-related differences in serum MFG-E8, TGF-β1 and correlation to the severity of atherosclerosis determined by ultrasound
| Autor: | Huanhuan Zhang, Huiying Zhao, Xiujiao Qin |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Carotid Artery Diseases Male 0301 basic medicine Aging Cancer Research medicine.medical_specialty Pathology 030204 cardiovascular system & hematology Biology Carotid Intima-Media Thickness Severity of Illness Index Biochemistry Gastroenterology Transforming Growth Factor beta1 Pathogenesis 03 medical and health sciences 0302 clinical medicine Internal medicine Severity of illness Genetics medicine Humans Molecular Biology Aged Ultrasonography Inflammation Oncogene Tumor Necrosis Factor-alpha business.industry Ultrasound Cancer Middle Aged Intercellular Adhesion Molecule-1 Milk Proteins medicine.disease Molecular medicine 030104 developmental biology Oncology Antigens Surface Molecular Medicine Female Tumor necrosis factor alpha business Biomarkers Transforming growth factor |
| Zdroj: | Molecular Medicine Reports. 16:9741-9748 |
| ISSN: | 1791-3004 1791-2997 |
| Popis: | Atherosclerosis (AS) is an age‑related inflammatory disease. Globule‑epidermal growth factor‑8 (MFG‑E8) and transforming growth factor-β1 (TGF‑β1) are involved in the pathogenesis of AS. However, age‑related changes in circulating levels of MFG‑E8 and TGF‑β1, and their correlation with the severity of AS is not well‑characterized. In this study, we investigated age‑related changes in serum levels of MFG‑E8, TGF‑β1 and examined their association with the severity of AS. Sixty healthy volunteers were divided into young, middle‑age and old‑age groups. In addition, carotid ultrasound examination was performed to assess the intima‑media thickness (IMT) of carotid artery. Sixty‑seven patients with carotid AS and 30 age‑matched healthy persons were divided into IMT increased group, plaque group and control group. Serum levels of MFG‑E8, TGF‑β1, tumor necrosis factor-α (TNF‑α) and intercellular adhesion molecule‑1 were measured in all subjects. A positive association between serum MFG‑E8 levels and age was observed in healthy volunteers, while a significant negative association was observed between TGF‑β1 levels and age. Serum levels of MFG‑E8 and TNF‑α showed a positive correlation while those of TGF‑β1 showed a negative correlation with Crouse scores for carotid artery IMT (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|