Tanespimycin and Tipifarnib Exhibit Synergism in Inducing Apoptosis in Melanoma Cell Lines From Later Stages of Tumor Progression

Autor:	Anna Bentke, Piotr Laidler, Katarzyna Krzykowska-Petitjean, Barbara Ostrowska, Jędrzej Małecki
Rok vydání:	2013
Předmět:	Cancer Research Lactams Macrocyclic Antineoplastic Agents Apoptosis Protein Serine-Threonine Kinases Quinolones Biology Tanespimycin Pharmacology chemistry.chemical_compound Cell Line Tumor Benzoquinones medicine Humans HSP90 Heat-Shock Proteins Fragmentation (cell biology) Melanoma Cell Proliferation Caspase 3 Cell growth Drug Synergism General Medicine medicine.disease Caspase 9 Enzyme Activation Oncology chemistry Drug Resistance Neoplasm Tumor progression Cutaneous melanoma Cancer research Tipifarnib medicine.drug
Zdroj:	Cancer Investigation. 31:545-549
ISSN:	1532-4192 0735-7907
DOI:	10.3109/07357907.2013.830736
Popis:	Many anticancer strategies rely on efficient induction of apoptosis. The need for development of drug combinations with a strong pro-apoptotic activity is of particular interest in melanoma resistant to currently available chemotherapeutic regimes. We studied the pro-apoptotic properties of combination of tanespimycin + tipifarnib in five melanoma cell lines representing various stages of tumor progression. Our results show that in cells derived from vertical- and metastatic-phase the combination of tested drugs is strongly cytotoxic and efficient in inducing apoptosis, as evidenced by activation of caspase-9 and caspase-3 and enhanced fragmentation of DNA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e35f03b95909c2ff2bd499d8e133f65 https://doi.org/10.3109/07357907.2013.830736 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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