The effects of adenoidectomy of serum insulin-like growth factor-1 (IGF-1) and ghrelin in hypertrophied adenoids in children with otitis media with effusion
| Autor: | Bogdan Cylwik, Beata Żelazowska-Rutkowska, Bożena Skotnicka, Edwina Kasprzycka, Klaudia Jacewicz |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Adolescent medicine.medical_treatment Serum insulin Adenoid Gastroenterology Severity of Illness Index Adenoidectomy 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Insulin-Like Growth Factor I 030223 otorhinolaryngology Child business.industry Otitis Media with Effusion Growth factor Significant difference Ghrelin Otitis medicine.anatomical_structure Otorhinolaryngology Effusion Child Preschool Female medicine.symptom business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Otolaryngologia polska = The Polish otolaryngology. 74(4) |
| ISSN: | 2300-8423 |
| Popis: | Aim: The aim of the current study was to assess the serum levels of insulin-like growth factor-1 (IGF-1) and ghrelin in hypertrophied adenoids in children suffering with or without otitis media with effusion before and after adenoidectomy. Material and methods: Serum IGF-1 and ghrelin concentrations were measured with specific enzyme-linked immunoassay (ELISA) methods. The study was carried out in 20 children with otitis media with effusion. The reference group comprised 24 children with hypertrophied adenoid, while control group included 19 children. Results: This mean values of IGF-1 in children with otitis media with effusion and children with hypertrophied adenoid before adenoidectomy were significantly lower than those found in healthy children. Serum levels of IGF-1 were higher after adenoidectomy. There was a significant difference of serum ghrelin levels between both examined groups and the control group. Conclusion: Our results suggest that adenoidectomy in children with hypertrophied adenoids and in children with otitis media with effusion significantly increases the level of IGF-1 in serum compared to before surgery through the effect of the GH-IGF-1 axis, which could contribute to children’s growth. |
| Databáze: | OpenAIRE |
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