Isoxazole-3-hydroxamic acid derivatives as peptide deformylase inhibitors and potential antibacterial agents

Autor:	Patrizia Cali, Seema Mukhija, Lars Naerum, Anders Hjelmencrantz
Rok vydání:	2004
Předmět:	Models Molecular Staphylococcus aureus Stereochemistry Clinical Biochemistry Pharmaceutical Science Hydroxamic Acids Biochemistry Chemical synthesis Amidohydrolases chemistry.chemical_compound Peptide deformylase Structure-Activity Relationship Drug Discovery Escherichia coli Structure–activity relationship Isoxazole Molecular Biology Antibacterial agent chemistry.chemical_classification Hydroxamic acid biology Molecular Structure Organic Chemistry General Medicine Isoxazoles Combinatorial chemistry Anti-Bacterial Agents Enzyme inhibition Enzyme chemistry Enzyme inhibitor biology.protein Molecular Medicine
Zdroj:	Bioorganicmedicinal chemistry letters. 14(24)
ISSN:	0960-894X
Popis:	A series of isoxazole-3-hydroxamic acid derivatives has been identified as a new class of small, nonpeptidic inhibitors of peptide deformylase (PDF). The synthesis, enzyme inhibition and preliminary investigation of the binding mode of this potential antibacterial compounds are reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e30d85f5a4d1ec22e1fde4f0735492d https://pubmed.ncbi.nlm.nih.gov/15546716 Zobrazit plný text záznamu Full Text from ScienceDirect