Associations of Sedentary Patterns with Cardiometabolic Biomarkers in Physically Active Young Males
| Autor: | Yalan Wu, Wendy Y J Huang, Stephen H.S. Wong, Xiao Yu Tian, Fenghua Sun, Sinead Sheridan, Chen Zheng |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Leptin Male SEDENTARY BREAKS medicine.medical_specialty Time Factors medicine.medical_treatment Vascular Cell Adhesion Molecule-1 Physical Therapy Sports Therapy and Rehabilitation Sitting Young Adult 03 medical and health sciences SEDENTARY BOUTS 0302 clinical medicine Insulin resistance Internal medicine SITTING TIME Humans Insulin Medicine Resistin Orthopedics and Sports Medicine Endothelial dysfunction Young adult Exercise Sitting Position C-Peptide Adiponectin business.industry Applied Sciences 030229 sport sciences medicine.disease Lipids ACTIVE ADULTS P-Selectin C-Reactive Protein Cross-Sectional Studies Endocrinology ENDOTHELIAL DYSFUNCTION Standing Position Insulin Resistance Sedentary Behavior E-Selectin business Biomarkers |
| Zdroj: | Medicine and Science in Sports and Exercise |
| ISSN: | 1530-0315 0195-9131 |
| DOI: | 10.1249/mss.0000000000002528 |
| Popis: | Purpose Sitting time (ST) is a serious global health issue and positively associated with cardiometabolic disease. The present study investigated associations between objectively measured ST, sedentary patterns, and cardiometabolic biomarkers in physically active young males. Methods Cross-sectional analysis was completed in 94 males 18–35 yr of age. Total ST, prolonged sedentary bouts (≥30 min with no interruption), and sedentary breaks (transitions from sitting/lying to standing/stepping) were assessed using activPAL. Lipids, insulin, C-peptide, C-reactive protein (CRP), vascular cellular adhesion molecule-1, intercellular adhesion molecule 1, E-selectin, P-selectin, leptin, resistin, and adiponectin were measured using assay kits. The expression of specific proteins related to endothelial dysfunction was determined using quantitative real-time polymerase chain reaction. Associations between total ST, prolonged sedentary bouts, and sedentary breaks with cardiometabolic biomarkers and total ST and levels of gene expression were assessed using generalized linear models. Results Total ST was significantly associated with triglycerides (B = 1.814), insulin (B = 2.117), homeostasis model assessment of insulin resistance (B = 0.071), and E-selectin (B = 2.052). Leptin (B = 0.086), E-selectin (B = 1.623), and P-selectin (B = 2.519) were significantly associated with prolonged sedentary bouts, whereas leptin (B = −0.017) and CRP (B = −0.016) were associated with sedentary breaks. After adjustment for moderate to vigorous physical activity, the associations between triglycerides (B = 2.048) and total ST, and between CRP (B = −0.016) and sedentary breaks, remained significant. E-selectin mRNA levels (B = 0.0002) were positively associated with ST with or without adjustment for moderate to vigorous physical activity. Conclusions Total ST and prolonged sedentary bouts were positively associated with several cardiometabolic biomarkers, with interruptions in ST potentially contributing to reduced cardiometabolic risk in physically active young male adults. |
| Databáze: | OpenAIRE |
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