Hypoglycemic effect of Taraxacum officinale root extract and its synergism with Radix Astragali extract

Autor:	Jingwen Li, Yang Guo, Jiayuan Luo, Yang Tianzhi, Yangyang Chai, Yihong Bao
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Flavonoid 030209 endocrinology & metabolism Dandelion Polysaccharide urologic and male genital diseases hypoglycemic effect 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Taraxacum officinale synergism medicine TX341-641 Radix Radix Astragali 030304 developmental biology Original Research chemistry.chemical_classification combination 0303 health sciences Glycogen Traditional medicine Nutrition. Foods and food supply Taraxacum officinale root medicine.disease chemistry Pyruvate kinase Food Science
Zdroj:	Food Science & Nutrition Food Science & Nutrition, Vol 9, Iss 4, Pp 2075-2085 (2021)
ISSN:	2048-7177
Popis:	Taraxacum officinale (dandelion) and Radix Astragali are traditional medicinal and edible plants with high nutritional value. In this study, the synergistic hypoglycemic effect of DRE and Radix Astragali extract (RAE) was evaluated. Our results showed that water extract of dandelion (DRE‐w), mainly containing polysaccharides (63.92 ± 1.82 mg/g), total flavonoid (2.57 ± 0.06 mg/g), total phenolic compounds (8.93 ± 0.34 mg/g), and saponins (0.54 ± 0.05 mg/g), exhibited significantly inhibitory effect on α‐glucosidase and α‐amylase. DRE‐w and RAE had synergistic hypoglycemic effect; we found that DRE‐w and its combination with RAE could relieve the state of insulin resistance in IR‐HepG2 cells. The combination could more significantly increase the glucose consumption and intracellular glycogen content, and improve the activity of hexokinase and pyruvate kinase in IR‐HepG2 cells. In summary, DRE and its combination with RAE can be developed as the drugs or functional foods for diabetes prevention and treatment. In this study, the effect of dandelion root extracts (DREs) on the hypoglycemic effect and analysis of active compounds were investigated. We found that DRE and RAE had synergistic hypoglycemic effect. We believe that the results of this research are significant to the development of functional foods and healthcare drugs with hypoglycemic effects.
Databáze:	OpenAIRE
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