Incretin-Based Antihyperglycemic Agents for the Management of Acute Ischemic Stroke in Patients with Diabetes Mellitus: A Review
Autor: | Konstantinos Tziomalos, Dimitrios Milonas, Triantafyllos Didangelos, Apostolos I. Hatzitolios |
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Rok vydání: | 2019 |
Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Antihyperglycemic Agents Incretin 030209 endocrinology & metabolism Context (language use) Review 030204 cardiovascular system & hematology Neuroprotection 03 medical and health sciences Diabetes mellitus 0302 clinical medicine Internal medicine Internal Medicine medicine cardiovascular diseases Risk factor Acute ischemic stroke Outcome Ischemic stroke business.industry Incretin-based antihyperglycemic agents medicine.disease Animal studies business |
Zdroj: | Diabetes Therapy |
ISSN: | 1869-6961 1869-6953 |
Popis: | Diabetes mellitus (DM) is a major risk factor for ischemic stroke. Moreover, patients with DM suffer more severe strokes and have worse functional outcome following an acute stroke than patients without DM. In this context, data from animal studies and emerging evidence from clinical studies suggest that incretin-based antihyperglycemic agents might exert beneficial effects in patients with DM who suffer ischemic stroke. It appears that these agents exert neuroprotective actions that might both reduce infarct size and promote recovery. The present review summarizes the evidence on the potential role of incretin-based antihyperglycemic agents in the management of acute ischemic stroke. |
Databáze: | OpenAIRE |
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