Can Immobilized Artificial Membrane Chromatography Support the Characterization of Antimicrobial Peptide Origin Derivatives?
| Autor: | Katarzyna E. Greber, Hanna Kapica, Monika Pastewska, Wiesław Sawicki, Wojciech Kamysz, Krzysztof Rolka, Krzesimir Ciura, Natalia Ptaszyńska, Anna Łęgowska |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
cell-penetrating peptide (CPP) antimicrobial peptide medicine.drug_class Antibiotics Antimicrobial peptides Synthetic membrane Peptide RM1-950 Biochemistry Microbiology medicine Cationic Lipopeptides Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics chemistry.chemical_classification Chromatography biology Chemistry Communication transportan 10 (TP10-NH2) Antimicrobial biology.organism_classification Ciprofloxacin Infectious Diseases short cationic lipopeptides Therapeutics. Pharmacology IAM-HPLC Bacteria medicine.drug |
| Zdroj: | Antibiotics, Vol 10, Iss 1237, p 1237 (2021) Antibiotics |
| ISSN: | 2079-6382 |
| Popis: | The emergence and spread of multiple drug-resistant bacteria strains caused the development of new antibiotics to be one of the most important challenges of medicinal chemistry. Despite many efforts, the commercial availability of peptide-based antimicrobials is still limited. The presented study aims to explain that immobilized artificial membrane chromatography can support the characterization of antimicrobial peptides. Consequently, the chromatographic experiments of three groups of related peptide substances: (i) short cationic lipopeptides, (ii) citropin analogs, and (iii) conjugates of ciprofloxacin and levofloxacin, with a cell-penetrating peptide were discussed. In light of the discussion of the mechanisms of action of these compounds, the obtained results were interpreted. |
| Databáze: | OpenAIRE |
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