Impact of endometriosis on risk of ovarian, endometrial and cervical cancers: a meta-analysis
| Autor: | Lu Wang, Ruijuan Liu, Jia Li, Shifeng Tang, Tingting Zhang, Xue Wang, Wenge Zhao, Yan Yao, Changgang Sun, Fubin Feng, Cun Liu |
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| Rok vydání: | 2018 |
| Předmět: |
Risk
Oncology medicine.medical_specialty Genital Neoplasms Female Endometriosis Uterine Cervical Neoplasms Cochrane Library Cohort Studies Endometrium 03 medical and health sciences 0302 clinical medicine Internal medicine Odds Ratio medicine Humans Ovarian Neoplasms Cervical cancer 030219 obstetrics & reproductive medicine business.industry Endometrial cancer Obstetrics and Gynecology General Medicine medicine.disease Endometrial Neoplasms Case-Control Studies 030220 oncology & carcinogenesis Relative risk Meta-analysis Female business Ovarian cancer Cohort study |
| Zdroj: | Archives of Gynecology and Obstetrics. 299:35-46 |
| ISSN: | 1432-0711 0932-0067 |
| Popis: | The risks of gynecologic cancer have not been well established in women with endometriosis. The objective of the present study was to investigate the influence of endometriosis on the risk for three gynecologic cancer (ovarian cancer, endometrial cancer and cervical cancer). We gathered updated evidence about the risk relationship between endometriosis and gynecologic cancers by conducting a comprehensive search of several medical literature electronic databases, including PubMed, Embase and the Cochrane Library. The design and quality of all studies were evaluated using the Newcastle–Ottawa Scale (NOS), and a random-effects model was used to calculate pooled risk ratio (RR). Of the 8538 articles our search produced, we selected 25 qualified studies, including 16 cohort studies and 9 case–control studies. Patients with endometriosis had both an increased risk of ovarian cancer [RR 1.964; 95% CI (1.685, 2.290)]. The risk of endometrial cancer (EC) is not necessarily higher in patients with endometriosis [RR 1.176, 95% CI (0.878, 1.575)]. Endometriosis was not associated with an increased risk for cervical cancer (CC) [RR 0.670, 95% CI (0.537, 0.838)]. Patients with endometriosis need to be closely observed and rechecked regularly to prevent malignant changes. |
| Databáze: | OpenAIRE |
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