Associations of Gene Sequence Variation and Serum Levels of C-Reactive Protein and Interleukin-6 with Alzheimer's Disease and Dementia
| Autor: | Margaret Gatz, Chandra A. Reynolds, Ulrika K. Eriksson, Mun-Gwan Hong, Nancy L. Pedersen, Jonathan A. Prince, Paul W. Dickman, Anna M. Bennet |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Genotype Population Enzyme-Linked Immunosorbent Assay Single-nucleotide polymorphism Disease Biology Polymorphism Single Nucleotide Article Risk Factors Polymorphism (computer science) mental disorders Diseases in Twins medicine Humans Dementia Interleukin 6 education Aged Aged 80 and over Inflammation Analysis of Variance education.field_of_study Chi-Square Distribution Interleukin-6 General Neuroscience C-reactive protein Case-control study Genetic Variation General Medicine medicine.disease Psychiatry and Mental health Clinical Psychology C-Reactive Protein Case-Control Studies Immunology biology.protein Female Geriatrics and Gerontology |
| Zdroj: | Journal of Alzheimer's Disease. 23:361-369 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-2010-101671 |
| Popis: | Inflammatory mechanisms have been implicated in Alzheimer's disease (AD) and dementia. We therefore sought to study DNA sequence variation and serum levels of the potent inflammatory mediators Interleukin-6 (IL6) and C-reactive protein (CRP) in relation to AD and dementia. Tagging single nucleotide polymorphisms (tagSNPs) were chosen to capture most variation in and around CRP and IL6 in 3937 elderly Swedish men and women (1,265 AD cases). A sub-set of the population (n = 723) with serum measurements of CRP and IL6 was included in 1) a nested case-control study of incident dementia cases, and 2) a case-control study of prevalent dementia cases. None of the SNPs or haplotypes was significantly associated with AD or dementia after correcting for multiple testing nor were elevated baseline levels of hsCRP or IL6 (measured on average 4.3 years before dementia onset) significantly associated with risk of future AD or dementia. However, prevalent AD cases had higher levels of IL6 (measured on average 5.5 years after dementia onset) than age- and gender-matched controls, OR 2.24 (95% CI 1.27-3.95), p-value 0.006. In summary, this data suggests that AD patients have an altered immune profile with higher circul- ating levels of IL6 than age- and gender-matched controls. However, neither variation in the CRP and IL6 genes nor circulating levels of their respective protein products were associated with an increased risk of developing late-life dementias. |
| Databáze: | OpenAIRE |
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