Menopausal Hormone Therapy Is Associated With Reduced Total and Visceral Adiposity: The OsteoLaus Cohort
| Autor: | Gérard Waeber, Peter Vollenweider, Pedro Marques-Vidal, Elena Gonzalez Rodriguez, Didier Hans, Olivier Lamy, Georgios Papadakis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
030219 obstetrics & reproductive medicine business.industry Endocrinology Diabetes and Metabolism Biochemistry (medical) Clinical Biochemistry Confounding 030209 endocrinology & metabolism Context (language use) medicine.disease Biochemistry Menopause 03 medical and health sciences 0302 clinical medicine Endocrinology Hand strength Internal medicine Cohort Adiposity/drug effects Aged Aged 80 and over Body Composition/drug effects Bone Density/drug effects Cohort Studies Cross-Sectional Studies Down-Regulation/drug effects Estrogen Replacement Therapy/statistics & numerical data Estrogens/pharmacology Estrogens/therapeutic use Female Hand Strength Humans Intra-Abdominal Fat/drug effects Middle Aged Obesity Abdominal/epidemiology Obesity Abdominal/prevention & control Lean body mass medicine business Body mass index Cohort study |
| Zdroj: | The Journal of clinical endocrinology and metabolism, vol. 103, no. 5, pp. 1948-1957 |
| Popis: | Context After menopause, fat mass (FM) and visceral adipose tissue (VAT) increase and nonbone lean body mass (LBM) decreases. Whether menopausal hormone therapy (MHT) reverses these changes remains controversial. Objective To assess the effect of MHT on FM, VAT, and LBM before and after its withdrawal and evaluate potential confounders. Design Cross-sectional study. Setting General community. Patients or Other Participants Women of the OsteoLaus cohort (50 to 80 years old) who underwent dual-energy X-ray absorptiometry (DXA) with body composition assessment. After we excluded women with estrogen-modifying medications, the 1053 participants were categorized into current users (CUs), past users (PUs), and never users (NUs) of MHT. Intervention None. Main Outcome Measures VAT measured by DXA was the primary outcome. We assessed subtotal and android FM, LBM, muscle strength (hand grip), and confounding factors (caloric intake, physical activity, biomarkers). Results The groups significantly differed in age, NU < CU < PU. Age-adjusted VAT was lower in CUs than NUs (P = 0.03). CUs exhibited lower age-adjusted body mass index (BMI) (−0.9 kg/m2) and a trend for lower FM (−1.3 kg). The 10-year gain of VAT (P < 0.01) and subtotal and android FM (P < 0.05) was prevented in CUs. No difference in LBM or hand grip was detected. No residual effect was detected for PUs, including for early MHT discontinuers. The confounding factors did not significantly differ between groups except for higher caloric intake in PUs compared with NUs. Conclusions MHT is associated with significantly decreased VAT, BMI, and android FM. No benefit is detected for LBM. The benefits are not preserved in PUs, suggesting caution when MHT is discontinued. |
| Databáze: | OpenAIRE |
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