β-Sitosterol-loaded solid lipid nanoparticles ameliorate complete Freund’s adjuvant-induced arthritis in rats: involvement of NF-кB and HO-1/Nrf-2 pathway

Autor:	Bin Shi, Fengmei Cai, Zhiyu Liu, Xijing He, Feng Zhang, Zhanqi Li
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Male NF-E2-Related Factor 2 Freund's Adjuvant Pharmaceutical Science Arthritis Inflammation RM1-950 02 engineering and technology Pharmacology 030226 pharmacology & pharmacy Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Solid lipid nanoparticle medicine Animals Rats Wistar Hypolipidemic Agents Autoimmune disease Drug Carriers Dose-Response Relationship Drug business.industry β-Sitosterol NF-kappa B General Medicine HO-1/Nrf2 pathway 021001 nanoscience & nanotechnology medicine.disease Complete Freund's Adjuvant Sitosterols Rats arthritis inflammation Rheumatoid arthritis Heme Oxygenase (Decyclizing) Nanoparticles Therapeutics. Pharmacology medicine.symptom 0210 nano-technology business Research Article Signal Transduction
Zdroj:	Drug Delivery article-version (VoR) Version of Record Drug Delivery, Vol 27, Iss 1, Pp 1329-1341 (2020)
ISSN:	1521-0464 1071-7544
Popis:	Rheumatoid arthritis (RA), autoimmune disease that is categorized via chronic inflammation manifestation, obesity, cardiovascular risk and even enhanced the mortality and affect the 0.3 and 1% of population worldwide. The current experimental study was scrutinize the anti-arthritic effect of β-sitosterol loaded solid lipid nanoparticles (SLN) against complete Fruend adjuvant (CFA)-induced arthritis via dual pathway. Double emulsion solvent displacement method was used for the preparation of β-sitosterol solid lipid nanoparticles (SLN). CFA was used to induce arthritis and rats were divided into different groups for 28 days. Biochemical, anti-inflammatory, pro-inflammatory cytokines and inflammatory mediator were estimated, respectively. Receptor activator of nuclear factor kappa-B ligand (RANKL), signal transducer and activator of transcription-3 (STAT3) nuclear factor erythroid 2–related factor 2 (Nrf2), Heme Oxygenase-1(HO-1) and Nuclear factor-κB (NF-κB) expression were estimated. β-sitosterol-SLN significantly (p
Databáze:	OpenAIRE
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