Effects of stress-induced increases of corticosterone on circulating triglyceride levels, biliverdin concentration, and heme oxygenase expression
| Autor: | Jennifer A. Minnick, Michael W. Butler, Justin K. Hines, Scott E. Berger, Ellen Armour, Marissa L. Rossi, Sydney F. Schock |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
endocrine system medicine.medical_specialty Physiology Kidney Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Stress Physiological Corticosterone Internal medicine medicine Animals Molecular Biology Heme Triglycerides Biliverdin Triglyceride Biliverdine Lipid metabolism Heme oxygenase 030104 developmental biology medicine.anatomical_structure Endocrinology Liver chemistry Gluconeogenesis Heme Oxygenase (Decyclizing) Sparrows Spleen 030217 neurology & neurosurgery |
| Zdroj: | Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 240:110608 |
| ISSN: | 1095-6433 |
| Popis: | When exposed to stressors, animals physiologically respond by secreting glucocorticoid hormones. Most birds, reptiles, and amphibians secrete corticosterone (CORT), which allows them to maximize short-term survival, including by modulating lipid metabolism. However, the factors regulating lipid metabolism, particularly during acute (i.e., short-term) stressors, are not well-characterized. To investigate one putative mechanism, we examined how expression of the enzyme heme oxygenase (HO), which primarily converts heme into biliverdin, changes during an acute stressor. Because HO has links to decreased levels of triglycerides, we tested the hypothesis that an acute stressor increases HO expression, which would concomitantly decrease circulating lipid levels. We compared free-living house sparrow (Passer domesticus) nestlings exposed to a one-hour stressor to control individuals, and quantified HO expression and biliverdin concentration in spleen, liver, or kidney tissue, as well as circulating CORT, triglyceride, and glycerol levels. Nestlings exposed to a stressor had reduced circulating triglycerides consistent with an increased rate of gluconeogenesis during an acute stressor. Concentrations of triglycerides were also negatively correlated with HO expression in the liver, which is consistent with mammalian studies. However, contrary to our predictions, exposure to a stressor did not affect HO expression, or biliverdin concentration in liver, spleen, or kidney. Overall, our results support links between CORT, triglyceride levels, and HO expression, though the molecular pathways connecting these metrics still need to be elucidated. |
| Databáze: | OpenAIRE |
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