Association of an overlap syndrome of autoimmune hepatitis and primary biliary cirrhosis with cytomegalovirus infection
| Autor: | Makoto Ohbu, Megumi Toyoda-Akui, Hiroaki Yokomori, Hide Yoshida, Hajime Takeuchi, Tadashi Motoori, Yuki Shimizu, Hirobumi Kondo, Fumihiko Kaneko, Kumiko Tahara, Masaya Oda, Toshifumi Hibi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Pathology
medicine.medical_specialty enzyme linked immuno sorbent assay Anti-nuclear antibody medicine.diagnostic_test autoimmune hepatitis business.industry Congenital cytomegalovirus infection Overlap syndrome Case Report General Medicine Autoimmune hepatitis Jaundice medicine.disease primary biliary cirrhosis Primary biliary cirrhosis Liver biopsy fluorescence antinuclear antibody medicine cytomegalovirus infection medicine.symptom business Viral hepatitis |
| Zdroj: | International Journal of General Medicine |
| ISSN: | 1178-7074 |
| Popis: | A 63-year-old woman, who presented with severe jaundice and elevated serum conjugated bilirubin level, denied alcohol and drug use and showed no evidence of viral hepatitis. Based on clinical and laboratory features, she was diagnosed with autoimmune hepatitis with primary biliary cirrhosis. Hematological and immunochemical assays, radiographic imaging, clinical examination, and liver biopsy were conducted. Laboratory results were the following: negative for fluorescence antinuclear antibody, negative for antismooth muscle antibodies but positive for antinuclear antibody (enzyme-linked immunosorbent assay) and antimitochondrial M2 antibody, high titers of serum globulin, and positive for cytomegalovirus IgM. Liver biopsy showed submassive lobular necrosis, inflammation with broad areas of parenchymal collapse, and chronic nonsuppurative destructive cholangitis. The patient responded well to corticosteroid therapy. This case might illustrate an association between cytomegalovirus infection and the occurrence of autoimmune hepatitis. |
| Databáze: | OpenAIRE |
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