Combined acetaminophen and ibuprofen for pain relief after oral surgery in adults: a randomized controlled trial
| Autor: | Elaine Davies, C. Frampton, J. Edwards, Graeme Ting, RD Gibbs, Brian J. Anderson, Alan Merry |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Visual analogue scale Analgesic Pain Ibuprofen Young Adult Pharmacokinetics Oral administration non-steroidal anti-inflammatory drugs Medicine Humans analgesics non-opioid acetaminophen Antipyretic Acetaminophen Pain Measurement Pain Postoperative analgesia postoperative business.industry organic chemicals Area under the curve Analgesics Non-Narcotic anaesthesia dental analgesics non-opioid ibuprofen Surgery Drug Combinations Anesthesiology and Pain Medicine Treatment Outcome Anesthesia Tooth Extraction Female Molar Third business medicine.drug |
| Zdroj: | BJA: British Journal of Anaesthesia |
| ISSN: | 1471-6771 |
| Popis: | Background Acetaminophen is often used with a non-steriodal anti-inflammatory drug for acute pain. Hitherto, these drugs have had to be given separately, typically at different time intervals. Maxigesic® tablets combine acetaminophen and ibuprofen in clinically appropriate doses to simplify administration and dosage regimen. We compared this combination with each of the constituent drugs for the relief of pain after extraction of third molar teeth. Methods Adults (more than 16 yr) having one or more wisdom teeth removed under general or local anaesthesia were instructed to take two tablets before operation, then two tablets every 6 h for up to 48 h of: (i) a combination of acetaminophen 500 mg and ibuprofen 150 mg per tablet (Maxigesic®); (ii) acetaminophen 500 mg per tablet alone; or (iii) ibuprofen 150 mg per tablet alone. The primary outcome measure was the area under the curve (AUC) of the 100 mm visual analogue scale pain measurements taken for up to 48 h after surgery, divided by time, at rest and on activity. Pharmacokinetic data were collected in a subset of patients. Results The mean (sem) time-corrected AUC on rest and activity, respectively, were: combination group 22.3 (3.2) and 28.4 (3.4); acetaminophen group 33.0 (3.1) and 40.4 (3.3); and ibuprofen group 34.8 (3.2) and 40.2 (3.4); P |
| Databáze: | OpenAIRE |
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