Unilateral vocal cord adductor weakness: an atypical manifestation of motor neurone disease
| Autor: | Christine Wools, Saiumaeswar Yogakanthi, Susan Mathers |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty Weakness Movement disorders Cord business.industry Short Report Neurosciences. Biological psychiatry. Neuropsychiatry Disease Gene mutation Motor neuron medicine.disease medicine.anatomical_structure Neurology otorhinolaryngologic diseases motor neuron disease medicine movement disorders Neurology (clinical) Amyotrophic lateral sclerosis medicine.symptom business Motor neurone disease RC321-571 |
| Zdroj: | BMJ Neurology Open BMJ Neurology Open, Vol 3, Iss 2 (2021) |
| ISSN: | 2632-6140 |
| DOI: | 10.1136/bmjno-2021-000205 |
| Popis: | BackgroundBulbar involvement is a recognised feature of motor neuron disease/amyotrophic lateral sclerosis (MND/ALS), both as a presenting complaint and as a consequence of advancing disease. Hoarseness and dysphonia have been associated with vocal cord abductor weakness. This is usually bilateral and has also been reported as the presenting clinical feature in a handful of patients with superoxide dismutase 1 (SOD1) gene mutations. Presentation with an isolated, unilateral vocal cord adductor weakness, however, is atypical and rare.CaseIn this report, we detail the case of a 38-year-old woman with dysphonia and a family history of an SOD1 mutation. Neurological features remained confined to the territory of the left vagus nerve for the next 12 months, before a more rapid rate of disease dissemination and progression.ConclusionsThis case highlights the importance of recognition of vocal cord palsy as an early manifestation of MND/ALS and the critical need for monitoring to recognise potential disease progression. |
| Databáze: | OpenAIRE |
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