Effects of withdrawal from long-term diphenylhydantoin treatment on audiogenic and maximal electroshock-induced seizures in rats
| Autor: | Thereza C. M. De Lima, João Palermo Neto |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Electroshock business.industry Central nervous system technology industry and agriculture Brain General Medicine Pharmacology medicine.disease Rats Drug withdrawal Maximal electroshock medicine.anatomical_structure Acoustic Stimulation Neurology Seizures Phenytoin Convulsant medicine Animals lipids (amino acids peptides and proteins) Neurology (clinical) business |
| Zdroj: | Acta Neurologica Scandinavica. 63:189-196 |
| ISSN: | 1600-0404 0001-6314 |
| DOI: | 10.1111/j.1600-0404.1981.tb00771.x |
| Popis: | Rats withdrawal from long-term diphenylhydantoin treatment (DPH) were tested for their sensibility to convulsant stimuli. Animals were more sensitive to convulsions elicited by maximal electroshock and sound, respectively, at 48 and 72 h after drug removal. These results suggest that long-term DPH treatment might develop a central nervous system supersensitivity state. |
| Databáze: | OpenAIRE |
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