Serum C3 and uterine artery Doppler indices at 14-20 weeks gestation for preeclampsia screening in low-risk primigravidas: A prospective observational study
| Autor: | Mai Salah Eldin, Abdelatif Galal Elkholy, Laila Aly Farid, Mostafa Fouad Gomaa, Osama Saleh Elkady |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Risk medicine.medical_specialty Adolescent Immunology Population Gestational Age Gravidity Sensitivity and Specificity Preeclampsia 03 medical and health sciences Young Adult 0302 clinical medicine Pre-Eclampsia Predictive Value of Tests Pregnancy medicine.artery Immunology and Allergy Medicine Humans Prospective Studies education Prospective cohort study Uterine artery Gynecology education.field_of_study 030219 obstetrics & reproductive medicine business.industry Obstetrics Obstetrics and Gynecology Gestational age Ultrasonography Doppler Blood Proteins Complement C3 medicine.disease Uterine Artery 030104 developmental biology Reproductive Medicine Predictive value of tests Gestation Female business |
| Zdroj: | Journal of reproductive immunology. 117 |
| ISSN: | 1872-7603 |
| Popis: | Problem Preeclampsia affects 2–10% of human pregnancies with poor screening tests. In order to intervene preventively, high risk population should be identified before the 20th week of pregnancy and by a method not subjected to operator efficiency. Methodology Prospective observational study recruiting 825 low risk primigravidas. Serum C3 and uterine artery Doppler indices were measured at 14–20 weeks. Results Serum C3 levels at 14–20 weeks of gestation had a sensitivity 83.3%, specificity 100%, PPV 100% and NPV 98.3% when the cut-off value was 53.1 mg/. For the mean RI, the best cut off value found was 0.72 with 100% sensitivity, 99.1% specificity, 92.3% PPV and 100% NPV. For the mean PI the best cut off value was 1.35 with 100% sensitivity, 94.1% specificity, 63.2% PPV and 100% NPV. The combination of serum C3 level and mean uterine artery PI showed 100% sensitivity, 97.4% specificity, 80% PPV and 100% NPV in prediction of PE. Conclusion Serum C3 levels at 14–20 weeks can be used for prediction of PE with comparable results to uterine artery Doppler indices but has the superiority of being operator independent. |
| Databáze: | OpenAIRE |
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