Aztreonam plus clindamycin vs. tobramycin plus clindamycin for the treatment of intraabdominal infections
| Autor: | Marcos F. Moraes, Olavo Soares de Souza, Dario Birolini |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty Adolescent Peritonitis Aztreonam medicine.disease_cause Gastroenterology chemistry.chemical_compound Random Allocation Pharmacotherapy Internal medicine Abdomen medicine Tobramycin Humans Adverse effect Child Aged Clinical Trials as Topic Gram-Negative Aerobic Bacteria Pseudomonas aeruginosa business.industry Clindamycin Bacterial Infections Middle Aged medicine.disease Infectious Diseases chemistry Superinfection Immunology Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Reviews of infectious diseases. 7 |
| ISSN: | 0162-0886 |
| Popis: | Sixty-six patients with acute intraabdominal infections due to gram-negative aerobic organisms were treated with aztreonam plus clindamycin or with tobramycin plus clindamycin in a multicenter, comparative, randomized study. The patients had undergone a variety of surgical procedures; most of them had peritonitis. Thirty-three of the 36 patients in the aztreonam group and 26 of the 30 patients in the tobramycin group had satisfactory clinical responses. Only one gram-negative aerobic pathogen, a strain of Pseudomonas aeruginosa, persisted after treatment; the patient involved was in the tobramycin group. The incidences of adverse reactions, superinfections, and abnormal laboratory values were low in each treatment group. The difference between the efficacies of the two regimens was not statistically significant. This study suggests that aztreonam may be a useful alternative to the aminoglycosides in the treatment of gram-negative intraabdominal infections. |
| Databáze: | OpenAIRE |
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