Sonographic Measurement of Mesenteric Fat Predicts Presence of Fatty Liver among Subjects with Polycystic Ovary Syndrome
| Autor: | C. W. K. Lam, Juliana C.N. Chan, Chun-Chung Chow, Michael Ho-Ming Chan, Wing-Yee So, Peter C.Y. Tong, Po Mui Lam, Lai Ping Cheung, Winnie C.W. Chu, Kin Hung Liu, C. S. Ho, Ronald C.W. Ma, G. T. C. Ko, Wing Hung Tam |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Subcutaneous Fat Adipose tissue Biochemistry Young Adult Endocrinology Sex hormone-binding globulin Waist–hip ratio Liver Function Tests Predictive Value of Tests Risk Factors Internal medicine polycyclic compounds Humans Medicine Mesentery reproductive and urinary physiology Ultrasonography Anthropometry biology medicine.diagnostic_test Waist-Hip Ratio business.industry fungi Biochemistry (medical) Fatty liver Hyperandrogenism food and beverages Glucose Tolerance Test medicine.disease Lipids Polycystic ovary Blood Cell Count Fatty Liver medicine.anatomical_structure Adipose Tissue biology.protein Female Waist Circumference business Liver function tests Blood Chemical Analysis hormones hormone substitutes and hormone antagonists Polycystic Ovary Syndrome |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 96:799-807 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2010-1608 |
| Popis: | Visceral fat is believed to be important in the pathogenesis of metabolic syndrome and fatty liver. In this study, we examined the relationship between mesenteric fat thickness and other sonographic indices of adiposity and the presence of fatty liver among subjects with polycystic ovary syndrome (PCOS).A total of 117 Chinese subjects with PCOS were evaluated (mean age, 28.6 ± 6.5 yr; mean body mass index, 24.3 ± 5.3 kg/m(2)). Anthropometric measurements and metabolic risk profile, including a standard oral glucose tolerance test, were assessed in all subjects. All subjects underwent an ultrasound examination for measurement of thickness of mesenteric, preperitoneal, and sc fat as well as evaluation for fatty liver.Forty-six (39.3%) of the subjects had fatty liver. PCOS subjects with fatty liver had higher body mass index, waist circumference, waist-hip ratio, and systolic blood pressure; a more unfavorable lipid profile with higher triglyceride; lower high-density lipoprotein cholesterol; higher fasting glucose and insulin; higher 2-h glucose during oral glucose tolerance test; lower SHBG; and higher alanine aminotransferase. Subjects with fatty liver had increased thickness of preperitoneal, mesenteric, and sc fat, as well as increased carotid intima-media thickness. Abdominal fat thickness showed moderate correlation to alanine aminotransferase as well as fasting insulin. On multivariate logistic regression, fasting insulin and mesenteric fat thickness were identified as independent predictors of fatty liver among subjects with PCOS.Fatty liver is present in a significant proportion of Chinese patients with PCOS. Sonographic measurement of mesenteric fat is an independent determinant of fatty liver among subjects with PCOS and identifies subjects at increased cardiovascular risk. |
| Databáze: | OpenAIRE |
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