Down syndrome: Distribution of brain amyloid in mild cognitive impairment

Autor: David Keator, Michael A. Yassa, Lisa Taylor, Diana Rosas, Sharon J. Krinsky-McHale, Dana Nguyen, Erin E. Ballard, Adam M. Brickman, Ira T. Lott, Wayne Silverman, William C. Kreisl, Michael J. Phelan, Christy Hom, Florence Lai, Julie C. Price, Margaret B. Pulsifer, Eric Doran, Nicole Schupf
Rok vydání: 2020
Předmět:
ABC-DS
Aging
Down syndrome
lcsh:Geriatrics
Neurodegenerative
Audiology
lcsh:RC346-429
0302 clinical medicine
Medicine
Cognitive impairment
Diagnostic Assessment & Prognosis
0303 health sciences
biology
amyloid
Alzheimer's disease
Psychiatry and Mental health
Neurological
medicine.medical_specialty
Amyloid
Amyloid beta
Intellectual and Developmental Disabilities (IDD)
ADDS
Article
03 medical and health sciences
Frontal regions
Behavioral and Social Science
mental disorders
Acquired Cognitive Impairment
Genetics
Dementia
AV-45
Amyloid burden
ABC‐DS
lcsh:Neurology. Diseases of the nervous system
030304 developmental biology
business.industry
Neurosciences
Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)
medicine.disease
MCI
Brain Disorders
lcsh:RC952-954.6
Alzheimers disease
AV‐45
PET
Posterior cingulate
biology.protein
Neurology (clinical)
business
030217 neurology & neurosurgery
dementia
Zdroj: Alzheimer's & dementia (Amsterdam, Netherlands), vol 12, iss 1
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
ISSN: 2352-8729
Popis: Author(s): Keator, David B; Phelan, Michael J; Taylor, Lisa; Doran, Eric; Krinsky-McHale, Sharon; Price, Julie; Ballard, Erin E; Kreisl, William C; Hom, Christy; Nguyen, Dana; Pulsifer, Margaret; Lai, Florence; Rosas, Diana H; Brickman, Adam M; Schupf, Nicole; Yassa, Michael A; Silverman, Wayne; Lott, Ira T | Abstract: IntroductionDown syndrome (DS) is associated with a higher risk of dementia. We hypothesize that amyloid beta (Aβ) in specific brain regions differentiates mild cognitive impairment in DS (MCI-DS) and test these hypotheses using cross-sectional and longitudinal data.Methods18F-AV-45 (florbetapir) positron emission tomography (PET) data were collected to analyze amyloid burden in 58 participants clinically classified as cognitively stable (CS) or MCI-DS and 12 longitudinal CS participants.ResultsThe study confirmed our hypotheses of increased amyloid in inferior parietal, lateral occipital, and superior frontal regions as the main effects differentiating MCI-DS from the CS groups. The largest annualized amyloid increases in longitudinal CS data were in the rostral middle frontal, superior frontal, superior/middle temporal, and posterior cingulate cortices.DiscussionThis study helps us to understand amyloid in the MCI-DS transitional state between cognitively stable aging and frank dementia in DS. The spatial distribution of Aβ may be a reliable indicator of MCI-DS in DS.
Databáze: OpenAIRE
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