Down syndrome: Distribution of brain amyloid in mild cognitive impairment
Autor: | David Keator, Michael A. Yassa, Lisa Taylor, Diana Rosas, Sharon J. Krinsky-McHale, Dana Nguyen, Erin E. Ballard, Adam M. Brickman, Ira T. Lott, Wayne Silverman, William C. Kreisl, Michael J. Phelan, Christy Hom, Florence Lai, Julie C. Price, Margaret B. Pulsifer, Eric Doran, Nicole Schupf |
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Rok vydání: | 2020 |
Předmět: |
ABC-DS
Aging Down syndrome lcsh:Geriatrics Neurodegenerative Audiology lcsh:RC346-429 0302 clinical medicine Medicine Cognitive impairment Diagnostic Assessment & Prognosis 0303 health sciences biology amyloid Alzheimer's disease Psychiatry and Mental health Neurological medicine.medical_specialty Amyloid Amyloid beta Intellectual and Developmental Disabilities (IDD) ADDS Article 03 medical and health sciences Frontal regions Behavioral and Social Science mental disorders Acquired Cognitive Impairment Genetics Dementia AV-45 Amyloid burden ABC‐DS lcsh:Neurology. Diseases of the nervous system 030304 developmental biology business.industry Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) medicine.disease MCI Brain Disorders lcsh:RC952-954.6 Alzheimers disease AV‐45 PET Posterior cingulate biology.protein Neurology (clinical) business 030217 neurology & neurosurgery dementia |
Zdroj: | Alzheimer's & dementia (Amsterdam, Netherlands), vol 12, iss 1 Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020) Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring |
ISSN: | 2352-8729 |
Popis: | Author(s): Keator, David B; Phelan, Michael J; Taylor, Lisa; Doran, Eric; Krinsky-McHale, Sharon; Price, Julie; Ballard, Erin E; Kreisl, William C; Hom, Christy; Nguyen, Dana; Pulsifer, Margaret; Lai, Florence; Rosas, Diana H; Brickman, Adam M; Schupf, Nicole; Yassa, Michael A; Silverman, Wayne; Lott, Ira T | Abstract: IntroductionDown syndrome (DS) is associated with a higher risk of dementia. We hypothesize that amyloid beta (Aβ) in specific brain regions differentiates mild cognitive impairment in DS (MCI-DS) and test these hypotheses using cross-sectional and longitudinal data.Methods18F-AV-45 (florbetapir) positron emission tomography (PET) data were collected to analyze amyloid burden in 58 participants clinically classified as cognitively stable (CS) or MCI-DS and 12 longitudinal CS participants.ResultsThe study confirmed our hypotheses of increased amyloid in inferior parietal, lateral occipital, and superior frontal regions as the main effects differentiating MCI-DS from the CS groups. The largest annualized amyloid increases in longitudinal CS data were in the rostral middle frontal, superior frontal, superior/middle temporal, and posterior cingulate cortices.DiscussionThis study helps us to understand amyloid in the MCI-DS transitional state between cognitively stable aging and frank dementia in DS. The spatial distribution of Aβ may be a reliable indicator of MCI-DS in DS. |
Databáze: | OpenAIRE |
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