Enantioselective Desymmetrization of cis-3,5-O-Arylidenecyclohexanones Catalyzed by Cinchona-Derived Quaternary Ammonium Salts

Autor:	Mauro F. A. Adamo, Malachi Gillick Healy, Andrea Mereu, Mauro Cortigiani
Rok vydání:	2019
Předmět:	biology 010405 organic chemistry Chemistry Organic Chemistry Enantioselective synthesis Cinchona 010402 general chemistry biology.organism_classification 01 natural sciences Desymmetrization 0104 chemical sciences Catalysis chemistry.chemical_compound Organic chemistry Ammonium
Zdroj:	The Journal of Organic Chemistry. 84:4112-4119
ISSN:	1520-6904 0022-3263
DOI:	10.1021/acs.joc.9b00108
Popis:	An enantioselective protocol for the desymmetrization of cis-3,5- O-arylidenecyclohexanones has been developed that proceeded under the catalysis of readily available and inexpensive Cinchona-derived quaternary ammonium salts. The synthetic relevance of the methodology was exemplified by the synthesis of a key intermediate that could be used in the preparation of the active pharmaceutical ingredient, paricalcitol (Zemplar).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1b23539a0309c3b530b1d76bbb4966 https://doi.org/10.1021/acs.joc.9b00108 Zobrazit plný text záznamu