Green One-pot Synthesis of Novel Polysubstituted Pyrazole Derivatives as Potential Antimicrobial Agents
| Autor: | Zahra Motraghi, Alireza Samzadeh-Kermani, Mohammad Mehdi Zahedi, Hamid Beyzaei, Reza Aryan |
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| Rok vydání: | 2017 |
| Předmět: |
Deep eutectic solvent
010405 organic chemistry Chemistry Aryl One-pot synthesis Pyrazole 010402 general chemistry Antimicrobial Glycerol/potassium carbonate 01 natural sciences Combinatorial chemistry 0104 chemical sciences Green synthesis lcsh:Chemistry Potassium carbonate chemistry.chemical_compound Antibacterial and antifungal activities Anti-Infective Agents lcsh:QD1-999 Yield (chemistry) Pyrazoles Polysubstituted pyrazoles Malononitrile |
| Zdroj: | Acta Chimica Slovenica, Vol 64, Iss 4, Pp 911-918 (2017) |
| ISSN: | 1318-0207 |
| Popis: | Various biological properties of natural and synthetic pyrazole derivatives such as anti-inflammatory, antimicrobial, neuroprotective, anticonvulsant, antidepressant and anticancer activities encouraged us to propose a new, fast, green and eco-friendly procedure for the preparation of some novel 5-amino-3-(aryl substituted)-1-(2,4-dinitrophenyl)-1H-pyrazole-4-carbonitriles. They were efficiently synthesized via one-pot two-step process reaction of malononitrile, 2,4-dinitrophenylhydrazine and different benzaldehydes in deep eutectic solvent (DES) glycerol/potassium carbonate. The products yield and reaction times were considerably improved in the presence of applied DES. Antibacterial effects of all newly synthesized pyrazoles in comparison with several common antibiotics were evaluated against a variety of Gram-positive and Gram-negative pathogenic bacteria. In addition to, their inhibitory activities on three fungi were compared to some current antifungal agents. The moderate to good antimicrobial potentials particularly against fungi were observed in the major heterocyclic compounds according to the IZD, MIC, MBC and MFC results. |
| Databáze: | OpenAIRE |
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