Dual-Functionalized Theranostic Nanocarriers
| Autor: | Tianyi Lu, Ratnesh Lal, Siddhartha Akkiraju, Chen Zhang, Woraphong Janetanakit, Karla Santacruz Gomez, Gennadi V. Glinsky, Yue Cao, Michael T. Hwang, Preston B. Landon, Vrinda Sant, Alexander H. Mo, Paul L. Sud, Samuel Dossou, David A. Colburn, Veronica I. Shubayev |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Theranostic Nanomedicine Silicon dioxide Golf Ball Metal Nanoparticles Janus particles Nanotechnology 02 engineering and technology Silicon Dioxide 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Gold Colloid chemistry.chemical_compound chemistry Colloidal gold Microscopy Electron Scanning General Materials Science Gold Nanocarriers 0210 nano-technology Metal nanoparticles |
| Zdroj: | ACS Applied Materials & Interfaces. 8:14740-14746 |
| ISSN: | 1944-8252 1944-8244 |
| Popis: | Nanocarriers with the ability to spatially organize chemically distinct multiple bioactive moieties will have wide combinatory therapeutic and diagnostic (theranostic) applications. We have designed dual-functionalized, 100 nm to 1 μm sized scalable nanocarriers comprising a silica golf ball with amine or quaternary ammonium functional groups located in its pits and hydroxyl groups located on its nonpit surface. These functionalized golf balls selectively captured 10-40 nm charged gold nanoparticles (GNPs) into their pits. The selective capture of GNPs in the golf ball pits is visualized by scanning electron microscopy. ζ potential measurements and analytical modeling indicate that the GNP capture involves its proximity to and the electric charge on the surface of the golf balls. Potential applications of these dual-functionalized carriers include distinct attachment of multiple agents for multifunctional theranostic applications, selective scavenging, and clearance of harmful substances. |
| Databáze: | OpenAIRE |
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