A robust two-gene oscillator at the core of Ostreococcus tauri circadian clock
| Autor: | Quentin Thommen, Benjamin Pfeuty, Pierre-Emmanuel Morant, Marc Lefranc, François-Yves Bouget, Florence Corellou, Constant Vandermoëre |
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| Přispěvatelé: | Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 (PhLAM), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche Interdisciplinaire [Villeneuve d'Ascq] (IRI), Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Droit et Santé-Université de Lille, Sciences et Technologies, Laboratoire d'Océanographie Microbienne (LOMIC), Observatoire océanologique de Banyuls (OOB), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), ANR-07-BSYS-0004,MINICLOCK,Modélisation de l'horloge circadienne dans un nouveau modèle biologique : l'Ostreococcus tauri(2007), Université de Lille, Sciences et Technologies-Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Observatoire océanologique de Banyuls (OOB), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Time Factors
Light Circadian clock TOC1 General Physics and Astronomy Computational biology Models Biological Quantitative Biology - Quantitative Methods Ostreococcus tauri 03 medical and health sciences 0302 clinical medicine Chlorophyta Circadian Clocks PACS: 87.17.Cf 87.17.Vf 87.17.Yt RNA Messenger Gene Quantitative Methods (q-bio.QM) Mathematical Physics 030304 developmental biology Physics 0303 health sciences biology Microarray analysis techniques Applied Mathematics Robustness (evolution) Proteins Statistical and Nonlinear Physics [SDV.BBM.MN]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular Networks [q-bio.MN] biology.organism_classification [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] Circadian Rhythm réseaux génétiques CLOCK Gene Expression Regulation horloges circadiennes FOS: Biological sciences oscillations [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM] 030217 neurology & neurosurgery |
| Zdroj: | Chaos: An Interdisciplinary Journal of Nonlinear Science Chaos: An Interdisciplinary Journal of Nonlinear Science, American Institute of Physics, 2010, 20 (4), pp.045108. ⟨10.1063/1.3530118⟩ Chaos: An Interdisciplinary Journal of Nonlinear Science, 2010, 20 (4), pp.045108. ⟨10.1063/1.3530118⟩ |
| ISSN: | 1054-1500 |
| DOI: | 10.1063/1.3530118⟩ |
| Popis: | The microscopic green alga Ostreococcus tauri is rapidly emerging as a promising model organism in the green lineage. In particular, recent results by Corellou et al. [Plant Cell, 21, 3436 (2009)] and Thommen et al. [PLoS Comput. Biol. 6, e1000990 (2010)] strongly suggest that its circadian clock is a simplified version of Arabidopsis thaliana clock, and that it is architectured so as to be robust to natural daylight fluctuations. In this work, we analyze time series data from luminescent reporters for the two central clock genes TOC1 and CCA1 and correlate them with microarray data previously analyzed. Our mathematical analysis strongly supports both the existence of a simple two-gene oscillator at the core of Ostreococcus tauri clock and the fact that its dynamics is not affected by light in normal entrainment conditions, a signature of its robustness. 13 pages |
| Databáze: | OpenAIRE |
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