Audiometric patterns in ototoxicity after radiotherapy and chemotherapy in patients of head and neck cancers

Autor: Monika Malgonde, Manoj Kumar, Prakash S Nagpure
Rok vydání: 2015
Předmět:
Superior hypogastric
Volunteers
Audiometric patterns
Intrathecal drug delivery system
medicine.medical_treatment
Bed sore
Continuing professional development
Pressure ulcer
Bedside ultrasound
Cancer pain
Interventions
Ultrasonography
Cancer
Decubitus ulcer
lcsh:R5-920
Health Policy
Celiac plexus block
Neurolytic
medicine.anatomical_structure
Palliative care
Middle ear
Sensorineural hearing loss
Original Article
medicine.symptom
lcsh:Medicine (General)
Lumbar sympathectomy
medicine.medical_specialty
Hearing loss
Prevalence of pain
Guidelines
Home care
Ototoxicity
medicine
otorhinolaryngologic diseases
Chemotherapy
Vertebroplasty
Radiotherapy
business.industry
Head and neck cancer
Public Health
Environmental and Occupational Health
medicine.disease
Surgery
Radiation therapy
Epidural opioids
Radiofrequency
Concomitant
Severe pain
Educational needs
business
Neurolysis
Evidence-based
Zdroj: Indian Journal of Palliative Care
Indian Journal of Palliative Care, Vol 21, Iss 2, Pp 164-167 (2015)
ISSN: 0973-1075
Popis: Introduction: Inspite of various strategies adopted to protect the sensitive structures during organ preservation strategies, radiation damage can occur from the pharyngotympanic tube to the brain stem auditory pathway causing hearing loss. The purpose of this study is to evaluate the audiometric abnormalities and characterize them among the patients of head and neck cancers who have undergone radiotherapy (RT) and chemoradiation therapy (CT+RT). Materials and Methods: Sixty-six histopathologically proven head and neck cancer patients receiving RT and 34 patients receiving concomitant CT + RT underwent evaluation for audiometric abnormalities from 1 st September 2010 to 31 st August 2012. Results: Hearing losses were predominately of sensorineural type and mild. Patients who received concomitant CT+RT experienced greater sensorineural hearing loss compared with patients treated with RT alone. A paired sample t-test was conducted to compare the hearing losses before therapy and 6 and 12 months after therapy and was found to be significant ( P < 0.05). It was found that hearing loss was persistent. Significant difference was found in the proportion of hearing loss after RT and RT+CT ( P < 0.05) after 1 month. In addition, mixed hearing loss occurred due to damage to the middle ear contents and can be improved if intervened appropriately.
Databáze: OpenAIRE
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