Influence of artificial sebum on the dermal absorption of chemicals in excised human skin: A proof-of-concept study
| Autor: | Désirée Schneider, Gintautas Korinth, Karl Heinz Schaller, Kathrin Dennerlein, Hans Drexler, Thomas Göen |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Administration Topical Skin Absorption Skin Cream Human skin Percutaneous penetration In Vitro Techniques Toxicology 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dermal penetration medicine Humans Diffusion cell Skin Ethanol Chromatography integumentary system General Medicine Penetration (firestop) Middle Aged Dermatology Toluene Sebum 030104 developmental biology chemistry Female |
| Zdroj: | Toxicology in vitro : an international journal published in association with BIBRA. 33 |
| ISSN: | 1879-3177 |
| Popis: | In an initial diffusion cell study, the influence of artificial sebum on dermal penetration and intradermal reservoir of ethanol and toluene was investigated in comparison with the effects of a skin cream (o/w- and w/o-emulsion) and untreated (control) skin. Human skin was exposed to neat ethanol and toluene for 4h, respectively. During the experiments, the penetration of the compounds was assessed in the receptor fluid. The amounts of the test compounds in the skin were determined at the end of exposure. In the control experiments, 42% of the total resorbed ethanol amounts were found in the intradermal reservoir after 4h, whereas 82% of the toluene amounts were found in the skin compartments. The treatment with artificial sebum showed no significant differences in dermal absorption of both test compounds compared to control skin. In contrast, the treatment with skin cream increased the percutaneous penetration (p |
| Databáze: | OpenAIRE |
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