Peripheral sensory neuropathy and cisplatin chemotherapy
| Autor: | Joanne Rogin, Leon Rosenberg, William Hrushesky, Robert I. Roelofs |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_treatment Motor nerve Sural nerve Sensory system Sensation Medicine Humans Ovarian Neoplasms Chemotherapy Carcinoma Transitional Cell business.industry Ureteral Neoplasms Carcinoma Peripheral Nervous System Diseases Tendon Motor unit medicine.anatomical_structure Urinary Bladder Neoplasms Doxorubicin Anesthesia Reflex Drug Therapy Combination Female Neurology (clinical) Cisplatin business |
| Zdroj: | Neurology. 34(7) |
| ISSN: | 0028-3878 |
| Popis: | Patients with advanced cancer, previously untreated, were given 60 mg/m2 cisplatin plus 60 mg/m2 adriamycin by monthly intravenous injections. Signs and symptoms of a predominantly sensory peripheral neuropathy developed in 92% of the patients. Patients complained of dysesthesias and paresthesias in hands and feet. Clinically, there was progressive decrease or loss of tendon reflexes, decreased vibratory sense, and mild decrease in light touch and pin sensation. Distal sensory latencies became prolonged or dropped out completely, but there was little change in motor nerve conduction velocities or motor unit action potentials. Sural nerve biopsies showed loss of large-diameter nerve fibers, with axonal and myelin degeneration. |
| Databáze: | OpenAIRE |
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