Prolonged Viral Shedding in Patients with Mild to Moderate COVID-19 Disease: A Regional Perspective
| Autor: | Rosemary Aldrich, Caroline Bartolo, Raquel Cowan, James Knox, David Lister, Mehrab E Hossain, Robert J. Commons, Paul M Kinsella |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19) Disease 01 natural sciences Asymptomatic lcsh:Infectious and parasitic diseases 03 medical and health sciences shedding 0302 clinical medicine Internal medicine Medicine mild In patient lcsh:RC109-216 030212 general & internal medicine 0101 mathematics Viral shedding Mild disease Original Research business.industry Transmission (medicine) SARS-CoV-2 010102 general mathematics Australia COVID-19 Increased risk medicine.symptom business |
| Zdroj: | Infectious Diseases, Vol 14 (2021) Infectious Diseases |
| ISSN: | 1178-6337 |
| Popis: | Background The risk of transmission of Coronavirus Disease 2019 (COVID-19) is increasingly understood to be greatest early after symptom onset, however, factors associated with prolonged and increased risk of transmission remain unclear. In settings where COVID-19 prevalence is low, there may be a benefit of extending the period that patients are isolated to decrease the risk of transmission. This study explored the duration of viral shedding in such a location, in patients with mild-moderate COVID-19 disease in Ballarat, Australia. Methods Patients diagnosed with COVID-19 disease using a real-time reverse-transcriptase–polymerase-chain-reaction (RT-PCR) assay from oropharyngeal and bilateral deep nasopharyngeal sampling and managed through Ballarat Health Services between March 1 and May 1, 2020 were included. Patients were retested if they were afebrile for >72 hours, asymptomatic and >14 days since symptom onset. If positive on retesting, patients were tested every 3 to 7 days thereafter. Results Patients underwent testing a median of 4 days (range 1-12) after initial symptom onset. Duration of symptoms ranged from 1 to 36 days. Positive tests were recorded up to a median of day 21 (range 6-38). Cycle thresholds were inversely correlated with time since symptom onset ( P 7 days after initial symptom onset had recrudescence of mild symptoms on day 13 and 14; both tested positive on follow-up tests at this time. Conclusions This study demonstrates prolonged shedding of COVID-19 in patients with mild-moderate disease. It suggests that some patients with mild disease may have recrudescence of symptoms a week or more after their initial symptoms resolved. |
| Databáze: | OpenAIRE |
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