The early response to major trauma and intramedullary nailing
| Autor: | Donald Salter, J Christie, R E Clutton, C M Robinson, D. G. Swann, Timothy O White |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Soft Tissue Injuries Medullary cavity Embolism Hemodynamics Bone Nails law.invention Intramedullary rod law Stress Physiological Fracture fixation medicine Animals Orthopedics and Sports Medicine Blood Coagulation Fractures Comminuted Sheep business.industry Major trauma medicine.disease Surgery Fracture Fixation Intramedullary Tibial Fractures Disease Models Animal Anesthesia Orthopedic surgery Wounds and Injuries business Trauma surgery Femoral Fractures |
| Zdroj: | The Journal of bone and joint surgery. British volume. 88(6) |
| ISSN: | 0301-620X |
| Popis: | The stress response to trauma is the summation of the physiological response to the injury (the ‘first hit’) and by the response to any on-going physiological disturbance or subsequent trauma surgery (the ‘second hit’). Our animal model was developed in order to allow the study of each of these components of the stress response to major trauma. High-energy, comminuted fracture of the long bones and severe soft-tissue injuries in this model resulted in a significant tropotropic (depressor) cardiovascular response, transcardiac embolism of medullary contents and activation of the coagulation system. Subsequent stabilisation of the fractures using intramedullary nails did not significantly exacerbate any of these responses. |
| Databáze: | OpenAIRE |
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