Red cell alloimmunization in sickle cell disease
| Autor: | A. C. Mcwilliam, Milica Brozovic, Sally C. Davies, A. Devenish, Patricia Hewitt |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Blood transfusion Anemia medicine.medical_treatment Anemia Sickle Cell Sickle Cell Trait Isoantibodies ABO blood group system medicine Humans Blood Transfusion Child Rh-Hr Blood-Group System biology Red Cell Kell Blood-Group System business.industry Hematology medicine.disease Sickle cell anemia Red blood cell medicine.anatomical_structure Hemoglobinopathy Blood Grouping and Crossmatching Immunology Blood Group Antigens biology.protein Antibody business |
| Zdroj: | British Journal of Haematology. 63:241-245 |
| ISSN: | 0007-1048 |
| Popis: | Alloimmunization to red cell antigens contributes to morbidity in transfused patients. It has been recommended that blood for sickle cell patients need not be matched for antigens other than ABO and Rh(D), as there is no greater incidence of antibody production than in other multitransfused patient populations. Post transfusion alloimmunization was studied in a group of 34 sickle cell disease patients attending a U.K. haemoglobinopathy clinic. Red cell antibodies were formed in 17.6% of the transfused patients and Rhesus and Kell antibodies accounted for 66% of this total. In order to reduce alloimmunization, a policy of performing extended red cell phenotyping on the patients, and providing blood matched for Kell, and in certain circumstances the Rhesus antigens other than Rh(D), is recommended. |
| Databáze: | OpenAIRE |
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