Effects of ceftriaxone on ischemia/reperfusion injury in rat brain
| Autor: | Sedat Meydan, H.M. Okuyan, Nebi Yilmaz, Kemal Turker Ulutas, Murat Altaş, Ahmet Nacar, Mustafa Aras |
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| Přispěvatelé: | MEYDAN, SEDAT |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Antioxidant medicine.medical_treatment Ischemia Superoxide dismutase activity Antioxidants Brain Ischemia Brain ischemia chemistry.chemical_compound Physiology (medical) Internal medicine Animals Medicine Rats Wistar business.industry Ceftriaxone General Medicine medicine.disease Malondialdehyde Rat brain Rats Neuroprotective Agents Endocrinology Neurology chemistry Reperfusion Injury Anesthesia Surgery Neurology (clinical) business Reperfusion injury medicine.drug |
| Zdroj: | Journal of Clinical Neuroscience. 20:457-461 |
| ISSN: | 0967-5868 |
| Popis: | The aim of this study was to investigate the effect of ceftriaxone treatment against short-term global brain ischemia/reperfusion (I/R) injury in rats. The study was carried out on 30 Wistar-albino rats that were divided into three groups: control group (n = 10), I/R group (n = 10) and I/R-ceftriaxone group (n = 10). Malondialdehyde (MDA) levels were significantly increased in the I/R group in comparison with the control group (p < 0.001). MDA was significantly lower in the I/R-ceftriaxone group than in the I/R group (p < 0.05). Superoxide dismutase activity was significantly decreased in the I/R group and increased in the I/R-ceftriaxone group as compared with the control group. Glutathione peroxidase activity was significantly decreased in the I/R group and increased in the I/R-ceftriaxone group as compared with the I/R group and the control. Histopathologically, ceftriaxone provided morphological improvement compared with the I/R group. We concluded that ceftriaxone has neuron-protective effects due to its antioxidant properties as shown by a decrease in MDA overproduction and histological improvement in brain tissue. (C) 2012 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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