Pharmacologic, Dietary, and Psychological Treatments for Irritable Bowel Syndrome With Constipation: Cost Utility Analysis
Autor: | Peter R. Gibson, William D. Chey, Jane G. Muir, Eric D. Shah, Jessica K. Salwen-Deremer, Shanti Eswaran |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Medicine (General) Prescription drug Psychological intervention comparative effectiveness coverage Article economic analysis quality-adjusted life year 03 medical and health sciences chemistry.chemical_compound QALY 0302 clinical medicine R5-920 value value-based care IBS Markov medicine pricing incremental cost-effectiveness ratio 030212 general & internal medicine Intensive care medicine Linaclotide Irritable bowel syndrome health care economics and organizations irritable bowel syndrome Cost–utility analysis business.industry ICER Health Policy Public Health Environmental and Occupational Health medicine.disease Quality-adjusted life year Clinical trial chemistry 030211 gastroenterology & hepatology business Incremental cost-effectiveness ratio |
Zdroj: | MDM Policy & Practice MDM Policy & Practice, Vol 6 (2021) |
ISSN: | 2381-4683 |
Popis: | Introduction. Irritable bowel syndrome (IBS) is the most common gastroenterology referral and one of the most common gastrointestinal complaints in primary care. We performed a cost-utility analysis of the most common treatments available in general practice for IBS with constipation (IBS-C), the most expensive IBS subtype. Methods. We developed a decision analytic model evaluating guideline-recommended and Food and Drug Administration–approved drugs, supplements, and dietary/psychological interventions. Model inputs were derived from “global symptom improvement” outcomes in systematic reviews of clinical trials. Costs were derived from national datasets. Analysis was performed with a 1-year time horizon from patient and payer perspectives. We analyzed a prototypical managed-care health plan with no cost-sharing to the patient. Results. From a payer perspective, global IBS treatments (including low FODMAP, cognitive behavioral therapy [CBT], neuromodulators), which are not specific to the IBS-C bowel subtype were less expensive than on-label prescription drug treatments. From a patient perspective, on-label prescription drug treatment with linaclotide was the least expensive treatment strategy. Drug prices and costs to manage untreated IBS-C were most important determinants of payer treatment preferences. Effects of treatment on missed work-days and need for repeated appointments to complete treatment were the most important determinants of treatment preference to patients. Discussion. Due mostly to prescription drug prices, neuromodulators, low FODMAP, and CBT appear cost-effective compared to on-label drug treatments from a payer perspective in cost-utility analysis. These findings may explain common treatment barriers in clinical practice. |
Databáze: | OpenAIRE |
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