Effects of phentolamine, phenoxybenzamine and desipramine on clonidine-induced blockade of cardiac acceleration in the dog
| Autor: | A. Scriabine, John M. Stavorski |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Phenoxybenzamine Sympathetic nerve Stimulation Clonidine Dogs Phentolamine Heart Rate Desipramine Internal medicine medicine Animals Drug Interactions Pharmacology business.industry Heart Electric Stimulation Blockade Peripheral Endocrinology Anesthesia Female business medicine.drug |
| Zdroj: | European Journal of Pharmacology. 42:63-69 |
| ISSN: | 0014-2999 |
| Popis: | Clonidine reduced cardiac acceleration induced by low frequency eletrical stimulation of cardiac symphathetic nerve fibers in anesthetized and vagotomized dogs. This effect of clonidine was abolished by short periods of high frequency electrical stimulation. The inhibitory effect of clonidine was observed with 10- as well as with 90-sec periods of electrical stimulation of symphatetic nerve fibers; it was antagonized by phentolamine, phenoxybenzamine and desipramine. This suggests the presence of α-adrenoceptors ar the peripheral sympathetic nerve ending in the dog. |
| Databáze: | OpenAIRE |
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