Febrile transfusion reaction following initial transfusion in a man with immunoblastic lymphadenopathy and granulocyte autoantibodies
| Autor: | Shu Tsong Huang, John Lin, Eoline I. McGowan, Man-Chiu Poon, Marcel E. Conrad, Harry M. Barnes |
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| Rok vydání: | 1983 |
| Předmět: |
Male
Pathology medicine.medical_specialty Anemia Granulocyte medicine Humans Platelet Aged Autoantibodies biology business.industry Autoantibody Transfusion Reaction Hematology medicine.disease Immune complex medicine.anatomical_structure Immunoblastic Lymphadenopathy Immunology biology.protein Anemia Hemolytic Autoimmune Autoimmune hemolytic anemia Antibody Packed red blood cells business Erythrocyte Transfusion Granulocytes |
| Zdroj: | American journal of hematology. 14(1) |
| ISSN: | 0361-8609 |
| Popis: | A 69-year-old man with immunoblastic lymphadenopathy and autoimmune hemolytic anemia who had no previous exposure to blood products developed a severe febrile nonhemolytic transfusion reaction following the initial infusion of packed red blood cells. The reaction recurred with transfusion of packed red blood cells, but not when freeze-thawed red blood cells were used. Immunofluorescence techniques demonstrated granulocyte antibodies in his serum and on the surface of his granulocytes. Circulating immune complex, HLA, and platelet antibodies were not present. The granulocyte antibodies fluctuated in titers with disease activities, and could be completely removed from the serum by autologous granulocyte absorption. We conclude that our patient had granulocyte autoantibodies which probably produced febrile transfusion reactions. |
| Databáze: | OpenAIRE |
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