Varicella-zoster virus encephalitis in acquired immunodeficiency syndrome: Report of four cases
| Autor: | Françoise Gray, E. Dournon, F. Rozenberg, M. Mohr, Laurent Bélec, Francesco Scaravilli, Elizabeth Sinclair, M. C. Lescs |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Herpesvirus 3 Human Pathology medicine.medical_specialty Histology viruses Molecular Sequence Data Biology medicine.disease_cause Herpes Zoster Polymerase Chain Reaction Virus Herpesviridae Inclusion bodies Pathology and Forensic Medicine Physiology (medical) medicine Humans Human Immunodeficiency Virus Proteins Acquired Immunodeficiency Syndrome Base Sequence Varicella zoster virus Brain virus diseases medicine.disease Virology Neurology Giant cell Molecular Probes DNA Viral Encephalitis Female Neurology (clinical) Viral disease |
| Zdroj: | Neuropathology and Applied Neurobiology. 18:502-514 |
| ISSN: | 1365-2990 0305-1846 |
| DOI: | 10.1111/j.1365-2990.1992.tb00817.x |
| Popis: | Four patients with acquired immunodeficiency syndrome, a 27-year-old female intravenous drug abuser and three males (two drug addicts aged 27 and 33 years and a 40-year-old homosexual) presented with a rapidly progressive encephalopathy. Two had generalized varicella-zoster virus skin infection, one had had a regressive thoracic zoster rash 7 months previously and one had no history of cutaneous eruption. Neuropathological examination revealed, in each case, multifocal necrotic changes with numerous, intranuclear Cowdry type A inclusion bodies in glial cells, endothelial cells, macrophages and neurons, within and around the lesions. These inclusion bodies were stained positively for varicella-zoster virus by immunocytochemistry and contained herpes virus nucleocapsids by electron microscopy. Molecular biology using the polymerase-chain-reaction method demonstrated viral genome. In one case, zoster-induced non-inflammatory vasculopathy involved medium sized leptomeningeal vessels and was associated with circumscribed areas of cortico-subcortical infarction. In another case, varicella-zoster virus encephalitis was associated with human immunodeficiency virus encephalitis and a secondary cerebral lymphoma. Multinucleated giant cells expressing human immunodeficiency virus proteins in their cytoplasm, were found in the lymphomatous deposits and in the varicella-zoster virus necrotic lesions. In these latter lesions, Cowdry type A inclusion bodies could be seen in the nuclei of some multinucleated giant cells confirming previous observations of MGCs co-infected by HIV and CMV, and supporting the hypothesis that DNA viruses interact with HIV, thus increasing its effect. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text