Dialysis-Requiring Acute Kidney Injury in Denmark 2000-2012: Time Trends of Incidence and Prevalence of Risk Factors—A Nationwide Study
| Autor: | Christian Torp-Pedersen, Nicholas Carlson, Anne-Lise Kamper, Kristine Hommel, Tina Vilsbøll, Anne Merete Boas Soja, Jonas Bjerring Olesen, Gunnar Gislason |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Denmark medicine.medical_treatment Orthopedic Surgery 030232 urology & nephrology lcsh:Medicine Comorbidity Cohort Studies Pulmonary Disease Chronic Obstructive Elderly 0302 clinical medicine Risk Factors Neoplasms Chronic Kidney Disease Medicine and Health Sciences Prevalence Registries 030212 general & internal medicine lcsh:Science Aged 80 and over Multidisciplinary Incidence Liver Diseases Incidence (epidemiology) Acute kidney injury Acute Kidney Injury Middle Aged Nephrology Cardiovascular Diseases Female Hemodialysis Anatomy Research Article Cohort study medicine.medical_specialty Surgical and Invasive Medical Procedures Digestive System Procedures 03 medical and health sciences Musculoskeletal System Procedures Renal Dialysis Internal medicine Medical Dialysis Renal Diseases Diabetes Mellitus medicine Humans Renal replacement therapy Intensive care medicine Dialysis Aged Retrospective Studies business.industry lcsh:R Geriatric nephrology Biology and Life Sciences Kidneys Retrospective cohort study Renal System medicine.disease Drug Utilization Age Groups People and Places Population Groupings lcsh:Q Morbidity business |
| Zdroj: | PLoS ONE, Vol 11, Iss 2, p e0148809 (2016) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Introduction Dialysis-requiring acute kidney injury is a severe illness associated with poor prognosis. However, information pertaining to incidence rates and prevalence of risk factors remains limited in spite of increasing focus. We evaluate time trends of incidence rates and changing patterns in prevalence of comorbidities, concurrent medication, and other risk factors in nationwide retrospective cohort study. Materials and Methods All patients with dialysis-requiring acute kidney injury were identified between January 1st 2000 and December 31st 2012. By cross-referencing data from national administrative registries, the association of changing patterns in dialysis treatment, comorbidity, concurrent medication and demographics with incidence of dialysis-requiring acute kidney injury was evaluated. Results A total of 18,561 adult patients with dialysis-requiring AKI were identified between 2000 and 2012. Crude incidence rate of dialysis-requiring AKI increased from 143 per million (95% confidence interval, 137–144) in 2000 to 366 per million (357–375) in 2006, and remained stable hereafter. Notably, incidence of continuous veno-venous hemodialysis (CRRT) and use of acute renal replacement therapy in elderly >75 years increased substantially from 23 per million (20–26) and 328 per million (300–355) in 2000, to 213 per million (206–220) and 1124 per million (1076–1172) in 2012, respectively. Simultaneously, patient characteristics and demographics shifted towards increased age and comorbidity. Conclusions Although growth in crude incidence rate of dialysis-requiring AKI stabilized in 2006, continuous growth in use of CRRT, and acute renal replacement therapy of elderly patients >75 years, was observed. Our results indicate an underlying shift in clinical paradigm, as opposed to unadulterated growth in incidence of dialysis-requiring AKI. |
| Databáze: | OpenAIRE |
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