Fragment of human beta-fibrinogen induces a behavioral effect on mouse forced swimming
| Autor: | Shun Ohunuma, Junya Sugawara, Toshihiro Sugiyama, Yoshihiko Kawarada, Yutaka Masuda |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Physiology Fibrinopeptide B Peptide Biology Fibrinogen Biochemistry Mice Cellular and Molecular Neuroscience Endocrinology Dopamine Internal medicine medicine Animals Humans Premovement neuronal activity Amino Acid Sequence Peptide sequence Swimming chemistry.chemical_classification Antagonist Peptide Fragments chemistry Models Animal Sulpiride Psychomotor Performance medicine.drug |
| Zdroj: | Peptides. 23:409-411 |
| ISSN: | 0196-9781 |
| Popis: | We detected a peptide having a behavioral activity on mouse forced swimming from sera of healthy volunteers without affective and psychotic diseases. The amino acid sequence was GVNDNEEGF, which was found in the sequence of human β-fibrinogen. The synthesized peptide also showed the behavioral activity dose-dependently, but human fibrinopeptide B (QGVDNEEGFFSAR) did not. The activity was decreased by dopamine 1 antagonist SCH-23390, but not by dopamine 2 antagonist sulpiride. These findings strongly suggest that metabolism of human β-fibrinogen induces the fragment affecting the mouse behavior via the dopamine1 neuronal activity. |
| Databáze: | OpenAIRE |
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