Multi-Detector Characterization of Grape Seed Extract to Enable in silico Safety Assessment
| Autor: | Timothy R. Baker, Catherine Mahony, Vincent P. Sica |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
food.ingredient
Computer science In silico Dietary supplement 01 natural sciences threshold of toxicological concern dietary supplements lcsh:Chemistry 0404 agricultural biotechnology food tannins Vitis vinifera Grape seed 010401 analytical chemistry 04 agricultural and veterinary sciences General Chemistry 040401 food science Multi detector 0104 chemical sciences grape seed lcsh:QD1-999 Grape seed extract oligomeric proanthocyanidins Biochemical engineering Charged aerosol detector Clearance |
| Zdroj: | Frontiers in Chemistry, Vol 6 (2018) |
| ISSN: | 2296-2646 |
| Popis: | Demands for increased analytical rigor have been growing within the botanical and dietary supplement industry due to concerns relative to safety, efficacy, and quality. Adulteration, ambiguous definitions, and insufficient perspective on safety are some of the major issues that arise when selecting a botanical extract. Herein, our comprehensive analytical approach is detailed for the selection of grape seed extracts. This approach provided characterization for the constituents above a threshold of toxicological concern by subjecting the extract to UHPLC-UV-CAD-HRMS and GC-FID & GC-HRMS. Thus, constituents within a wide range of volatility were evaluated. Furthermore, the extract was compared to authenticated botanical materials to confirm that no adulteration took place and was also compared to other grape seed extract sources to confirm that the material falls within the general profile. Finally, these data were cleared via an in silico safety assessment based on the list of constituents above the threshold of toxicological concern. |
| Databáze: | OpenAIRE |
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