Challenges in Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN)
| Autor: | Michael R. Savona, Rami S. Komrokji, Brianna N Smith |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Myeloid Chronic myelomonocytic leukemia Article World health 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Internal medicine medicine Humans Thrombocytosis business.industry Myelodysplastic syndromes food and beverages Hematology medicine.disease Myelodysplastic-Myeloproliferative Diseases Leukemia medicine.anatomical_structure 030220 oncology & carcinogenesis Refractory anemia with ring sideroblasts Atypical chronic myeloid leukemia business 030215 immunology |
| Zdroj: | Clin Lymphoma Myeloma Leuk |
| ISSN: | 2152-2650 |
| DOI: | 10.1016/j.clml.2018.11.019 |
| Popis: | Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are hybrid group of chronic myeloid neoplasms combining features of both MDS and MPN. The World Health Organization classification coined this group designation in 2008 to include chronic myelomonocytic leukemia, atypical chronic myeloid leukemia, juvenile myelomoncoytic leukemia, refractory anemia with ring sideroblasts and thrombocytosis as a provisional entity, and MDS/MPN unclassified. In this review, we highlight the challenges in diagnosing this group of the diseases, summarize the updates in classification, and discuss recent evolving understanding of the genetic landscape. We review risk-stratification models and overview the current management largely adapted from current MDS or MPN therapies. We define clinical benefit of therapy based on new proposed response criteria developed specifically for these groups of neoplasms. Finally, we introduce future opportunities including the planned international ABN MARRO (A Novel therapy combinations in untreated MDS/MPN And Relapsed/Refractory Overlap Syndromes) clinical study led by the MDS/MPN International Working Group. |
| Databáze: | OpenAIRE |
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