Ongoing change of severe hand, foot, and mouth disease pathogens in Yunnan, China, 2012 to 2016
| Autor: | Lijiang Du, Yunjiao Luo, Jianlan Li, Zhaoqing Yang, Zengqing Du, Quan Gan, Haihao Zhang, Yilin Zhao, Shaohui Ma |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Serotype China Veterinary medicine Serogroup medicine.disease_cause Coxsackievirus a16 Hand-foot-and-mouth disease 03 medical and health sciences 0302 clinical medicine Virology Pediatric hospital medicine Humans 030212 general & internal medicine Enterovirus business.industry Enterovirus a71 medicine.disease Hospitals Infectious Diseases Infectious disease (medical specialty) Child Preschool Etiology Female 030211 gastroenterology & hepatology Hand Foot and Mouth Disease business |
| Zdroj: | Journal of Medical Virology. 91:881-885 |
| ISSN: | 0146-6615 |
| Popis: | Hand, foot, and mouth disease (HFMD) is a common infectious disease caused by enteroviruses (EVs). In this study, a total of 341 children with serious HFMD were admitted to a pediatric hospital in Yunnan, China in 2012 to 2016. EVs were detected in 283 specimens (83.0%) and were assigned to 17 EV types. Enterovirus A71 (EV-A71) was predominant, accounting for 41.6%, and was followed by coxsackievirus A16 (CV-A16; 18.8%), CV-A6 (9.1%), CV-A10 and E-9 (2.9%), CV-B5 (1.8%), CV-A9 (1.2%), E-30 (0.9%), E-18, CV-A4, C-B3, and CV-A2 (0.6%) and other EV types such as CV-A8, CV-A14, E-14, E-11, and CV-B4 (0.3%). All of the EV-A71 isolates belonged to C4a; the CV-A16 belonged to B1b or B1a, although the B1b strains were predominant; and CV-A6 belonged to D3. In 2012 to 2014, E-9 was the third most frequent serotype (8.2%, 5.0%, and 6.5%, respectively). E-9 was not detected in 2015 and 2016. CV-A6 was not detected in 2012 but was the second most frequent serotype (25.3%) in 2015. Active etiological surveillance of HFMD makes it necessary to be aware of these emerging pathogens. |
| Databáze: | OpenAIRE |
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