Effects of the essential oil of Alpinia zerumbet (Pers.) B.L. BurttR.M. Sm. on healing and tissue repair after partial Achilles tenotomy in rats
Autor: | Margarete Zanardo Gomes, Sonia Oliveira Lima, Tássia Virginia de Carvalho Oliveira, Danielle Souza de Santana, Edna Aragão Farias Cândido, Ricardo Luiz Cavalcanti de Albuquerque-Júnior, Rose Nely Pereira Filho, Beatriz Benny Sungaila Pereyra, Janaína Farias Cândido, Luciano Santos-Júnior |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Male medicine.medical_specialty food.ingredient RD1-811 Achilles Tendon law.invention 03 medical and health sciences 0302 clinical medicine food law Statistical significance Internal medicine medicine Oils Volatile Alpinia zerumbet Animals Rats Wistar Essential oil Inflammation Wound Healing biology Chemistry Sunflower oil Rats Anatomy Tissue repair biology.organism_classification 030104 developmental biology Endocrinology Tenotomy 030220 oncology & carcinogenesis Alpinia Surgery Analysis of variance Achilles tenotomy Collagen Type I collagen Phytotherapy |
Zdroj: | Acta Cirurgica Brasileira, Volume: 32, Issue: 6, Pages: 449-458, Published: JUN 2017 Acta Cirurgica Brasileira, Vol 32, Iss 6, Pp 449-458 (2017) Acta Cirúrgica Brasileira v.32 n.6 2017 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
ISSN: | 1678-2674 |
Popis: | Purpose: To investigate the cellular response to injury, analyzing histopathologic changes associated with increased cellularity, degeneration and disorganization of collagen fibers. Methods: Thirty wistar rats were divided in two groups after partial Achilles tenotomy: the right hind paw were treated with the essential oil of Alpinia zerumbet (EOAz), diluted to 33% (0.3 mL kg-1), and the left hind paw received sunflower oil for 3, 14, 30 and 90 days. Statistical significance was determined using a Chi-square and Pearson Correlation qualitative variables test. Moreover, Mann-Whitney U-test test for comparison between different groups of the same cell, one-way ANOVA, and Tukey’s test of quantitative measurement. Results: A decrease hyperemia (p < 0.001) was observed in the acute phase of inflammatory cell number (p < 0.001), whereas sub-acute phase was marked by significant correlation with macrophages in fibroblasts (r = 0.17, p = 0.03), with probable induction a dense and modeled tissue. At chronic phase, it was found an increase in the number of fibroblasts and a higher percentage of type I collagen fibers (78%) compared with control collagen fibers (55%). Conclusion: Oil of Alpinia zerumbet stimulated the process of maturation, organization and tissue repair which gave it greater resistance. |
Databáze: | OpenAIRE |
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