Reduced pro-coagulant phenotype of microparticles in pancreatic cancer patients on omega-3-supplemented gemcitabine treatment

Autor:	Wen Yuan Chung, A. B. Hackney, A.R. Dennison, Ali Arshad, Naomi Martin, J. Isherwood, F. Runau
Rok vydání:	2018
Předmět:	microparticles Nutrition and Dietetics business.industry Cancer Critical Care and Intensive Care Medicine medicine.disease Phenotype Gemcitabine Pancreatic cancer medicine Cancer research cancer omega-3 business medicine.drug
Zdroj:	Clinical Nutrition. 37:S13
ISSN:	0261-5614
DOI:	10.1016/j.clnu.2018.06.1114
Popis:	Pancreatic cancer (PC) is an aggressive cancer associated with advanced disease at diagnosis and lack of effective therapy. Microparticles (MP), biologically active nanoparticles shed from cells, are novel markers of inflammation and might contribute to the growth and spread of PC. The aim of this study is to determine the effects of omega-3 supplementation in PC patients. MP were isolated from blood taken from PC patients undergoing Gemcitabine treatment (n=9, CON), patients undergoing treatment supplemented with omega-3 fatty acids (n=18, Ω-3) and from healthy controls (n=6, HC). MP were stained with AnV (PS-MP) and anti-CD142 to identify those expressing tissue factor (TF), acquired and analysed using flow cytometry. Circulating MP in both groups of PC patients was significantly greater than HC (CON 84±17X105/ml (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dfe69f763968b3823ada9643294711f https://doi.org/10.1016/j.clnu.2018.06.1114 Zobrazit plný text záznamu Full Text from ScienceDirect