Enterovirulence of enterotoxigenic Bacteroides fragilis in gnotobiotic pigs
| Autor: | James E. Collins, David A. Benfield, L L Myers, J. R. Duimstra, W. C. Bradbury, D S Shoop |
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| Rok vydání: | 1991 |
| Předmět: |
0301 basic medicine
Diarrhea Crypt hyperplasia 040301 veterinary sciences Colon Swine Enterotoxin Microbiology 0403 veterinary science Bacteroides fragilis 03 medical and health sciences Enterotoxins Feces Intestinal mucosa medicine Animals Germ-Free Life Large intestine Intestinal Mucosa Cecum Swine Diseases General Veterinary biology 04 agricultural and veterinary sciences biology.organism_classification Clinical disease Bacteroides Infections Small intestine Intestines 030104 developmental biology medicine.anatomical_structure Microscopy Electron Scanning medicine.symptom |
| Zdroj: | Veterinary pathology. 28(6) |
| ISSN: | 0300-9858 |
| Popis: | A porcine isolate of enterotoxigenic Bacteroides fragilis colonized the intestinal tract and caused watery, nonhemorrhagic diarrhea when given orally to 12, 1- to 2-day-old gnotobiotic pigs. Diarrhea occurred 2 to 3 days post-inoculation and continued throughout the 4 to 6 day post-inoculation period. Diarrheic pigs became mildly anorexic and dehydrated. They developed intestinal lesions characterized by swelling, vacuolation, and exfoliation of enterocytes, and crypt hyperplasia throughout the large intestine and, to a lesser extent, in the distal small intestine. Bacterial adherence to, or invasion of, the intestinal mucosa was not detected. A porcine isolate of nonenterotoxigenic B. fragilis was administered orally to six control pigs. The isolate colonized the intestinal tract, but the pigs did not develop clinical disease or intestinal lesions. The pathogenetic mechanism of the disease may involve mediation by a soluble enterotoxin (or toxins) elaborated by B. fragilis. |
| Databáze: | OpenAIRE |
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