Gray matter differences in the anterior cingulate and orbitofrontal cortex of young adults with Internet gaming disorder: Surface-based morphometry
| Autor: | Deokjong Lee, Kee Namkoong, In Young Kim, Young-Chul Jung, Jinsick Park |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Full-Length Report Prefrontal Cortex Medicine (miscellaneous) Gyrus Cinguli behavioral disciplines and activities Internet gaming disorder Young Adult 03 medical and health sciences 0302 clinical medicine Region of interest Interview Psychological Image Processing Computer-Assisted medicine Humans Gyrus cinguli gray matter volume Gray Matter Young adult Prefrontal cortex Young male Anterior cingulate cortex Internet Organ Size General Medicine Anatomy cortical thickness Magnetic Resonance Imaging surface-based morphometry 030227 psychiatry Behavior Addictive Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Video Games nervous system risk/reward decision-making Orbitofrontal cortex Psychology psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Journal of Behavioral Addictions |
| ISSN: | 2063-5303 2062-5871 |
| Popis: | Background and aims Altered risk/reward decision-making is suggested to predispose individuals with Internet gaming disorder (IGD) to pursue short-term pleasure, despite long-term negative consequences. The anterior cingulate cortex (ACC) and the orbitofrontal cortex (OFC) play important roles in risk/reward decision-making. This study investigated gray matter differences in the ACC and OFC of young adults with and without IGD using surface-based morphometry (SBM). Methods We examined 45 young male adults with IGD and 35 age-matched male controls. We performed region of interest (ROI)-based analyses for cortical thickness and gray matter volume (GMV) in the ACC and OFC. We also conducted whole-brain vertex-wise analysis of cortical thickness to complement the ROI-based analysis. Results IGD subjects had thinner cortices in the right rostral ACC, right lateral OFC, and left pars orbitalis than controls. We also found smaller GMV in the right caudal ACC and left pars orbitalis in IGD subjects. Thinner cortex of the right lateral OFC in IGD subjects correlated with higher cognitive impulsivity. Whole-brain analysis in IGD subjects revealed thinner cortex in the right supplementary motor area, left frontal eye field, superior parietal lobule, and posterior cingulate cortex. Conclusions Individuals with IGD had a thinner cortex and a smaller GMV in the ACC and OFC, which are critical areas for evaluating reward values, error processing, and adjusting behavior. In addition, in behavioral control-related brain regions, including frontoparietal areas, they also had thinner cortices. These gray matter differences may contribute to IGD pathophysiology through altered risk/reward decision-making and diminished behavioral control. |
| Databáze: | OpenAIRE |
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