Association between HMGB1 and asthma: a literature review
| Autor: | S. Quartuccio, Eleonora Di Salvo, Marco Casciaro, Egidio Imbalzano, Teresa Crea, Sebastiano Gangemi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
lcsh:Immunologic diseases. Allergy Allergy Immunology Inflammation chemical and pharmacologic phenomena Review HMGB1 Alarmin Asthma COPD Cytokines HMGB-1 RAGE Immunology and Allergy Molecular Biology Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Mediator medicine biology business.industry medicine.disease 3. Good health respiratory tract diseases 030104 developmental biology 030220 oncology & carcinogenesis biology.protein medicine.symptom Airway business lcsh:RC581-607 |
| Zdroj: | Clinical and Molecular Allergy, Vol 15, Iss 1, Pp 1-9 (2017) Clinical and Molecular Allergy : CMA |
| ISSN: | 1476-7961 |
| DOI: | 10.1186/s12948-017-0068-1 |
| Popis: | Background Recently, some studies demonstrated that HMGB1, as proinflammatory mediator belonging to the alarmin family, has a key role in different acute and chronic immune disorders. Asthma is a complex disease characterised by recurrent and reversible airflow obstruction associated to airway hyper-responsiveness and airway inflammation. Objective This literature review aims to analyse advances on HMGB1 role, employment and potential diagnostic application in asthma. Methods We reviewed experimental studies that investigated the pathogenetic role of HMGB in bronchial airway hyper-responsiveness, inflammation and the correlation between HMGB1 level and asthma. Results A total of 19 studies assessing the association between HMGB1 and asthma were identified. Conclusions What emerged from this literature review was the confirmation of HMGB-1 involvement in diseases characterised by chronic inflammation, especially in pulmonary pathologies. Findings reported suggest a potential role of the alarmin in being a stadiation method and a marker of therapeutic efficacy; finally, inhibiting HMGB1 in humans in order to contrast inflammation should be the aim for future further studies. |
| Databáze: | OpenAIRE |
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